1. Mark L. Heaney, MD

    • Department of Medicine
      Division of Hematology/Oncology
    Headshot

    Mark Heaney received his undergraduate education at Harvard and graduate education at the University of Virginia where he received an M.D. and a Ph.D. in microbiology. After Internal Medicine residency at SUNY Stony Brook, he had fellowship training in Hematology and Medical Oncology at Memorial Sloan-Kettering Cancer Center. Dr. Heaney subsequently joined the faculty at Memorial Sloan-Kettering Cancer Center. As a member of the Leukemia Service for nearly 20 years, Dr. Heaney continued laboratory research, initially studying the cell surface receptors that govern white blood cell development and leukemia cell growth. More recently, he has focused on metabolic differences between leukemia cells and normal cells that can provide insight into how leukemias behave in the individual patient and how they respond to treatment. His finding that vitamin C has the potential to blunt the beneficial effects of chemotherapy has been widely cited.

    I have had a long-standing interest in and committment to some of the least common blood cancers. These include the myeloproliferative neoplasms like myelofibrosis, essential thrombocythemia, polycythemia vera and chronic myeloid leukemias but also include even rarer diseases like hairy cell leukemia, mastocytosis, large granular lymphocytic leukemia and the histiocyte diseases-- Langerhan's cell histiocytosis, Rosai-Dorfman disease and Erdheim-Chester disease. In addition to providing care based on personal experience with dozens of patients with these diseases and a comprehensive knowledge of the medical literature and evidence, I have attempted to develop clinical trials for most of these conditions to provide additional therapeutic options and cutting edge treatments.

    Dr. Heaney has also been an active clinical investigator. He has been the Principal Investigator of many clinical trials that have aimed at developing new treatments for leukemia. In particular, he has focused on new treatments of the myeloproliferative neoplasms, primary myelofibrosis, polycythemia vera and essential thrombocythemia, but has also studied new treatments for chronic myeloid leukemia, mastocytosis and Langerhans cell histiocytosis in keeping with his clinical expertise in rare blood cancers.

    Dr. Heaney joined the faculty at CUMC in January, 2013. He has continued his commitment to caring for patients with blood cancers, developing new treatments including cutting edge clinical trials, and laboratory research that concentrates on translating discoveries from the bench to the bedside.

    Honors and Awards

    2008                                Abstract Reviewer and Oral Session Chair, ASH Annual Meeting

    2002                                Meet the Professor, ACP-ASIM Annual Meeting

    2001                                Hematology Fellows Attending Teaching Award, Memorial Sloan-Kettering

    1999                                Who’s Who In America

    1998-2001                     Translational Research Award, Leukemia and Lymphoma Society

    1996-2001                     Catherine and Frederick R. Adler Chair for Junior Faculty

    1993-1996                     NIH Physician Scientist Award

    1992                               Sloan-Kettering Clinical Scholar, Charles A. Dana Fellow

    1990                               American Cancer Society Clinical Fellow

     

    Presentations

    ASH Satellite Symposium: Faculty, Clinical Dialogues in Chronic Myelogenous Leukemia: Current Paradigms and Emerging Strategies, 2012

    Hospital for Special Surgery, Clinical Pathology Conference, 2010

    Speaker, Program Directors’ Workshop, American Society of Hematology, 2010

    Rockefeller University, Pugwash Lecture Series, 2009

    Irish Society of Medical Oncology, Dublin, Ireland, Grand Rounds, 2007

    Westchester County Medical Center, Hematology/Oncology Grand Rounds, 2006

    Walter Reed Army Medical Center, Grand Rounds, 2006

    Meet the Professor, ACP-ASIM Annual Meeting, 2002

    CUMC crown logoMark L. Heaney, MD
    is accepting new patients.
    Call (212) 305-5098 for appointments.

    Provider Information

    Board Certifications

    • Medical Oncology
    • Hematology
    • Internal Medicine

    Areas of Expertise

    • Acute Leukemia
    • Acute Lymphocytic Leukemia
    • Acute Myelogenous Leukemia
    • Acute Myeloid Leukemia
    • Aplastic Anemia
    • Chronic Leukemia
    • Chronic Lymphocytic Leukemia
    • Chronic Lymphoid Leukemia
    • Chronic Myelogenous Leukemia
    • Essential Thrombocythemia
    • Hairy Cell Leukemia
    • Hematologic Malignancy
    • Histiocytosis
    • Immune Thombocytopenic Purpura
    • Large Granular Lymphocytic Leukemia
    • Leukemia
    • Lymphoblastic Leukemia
    • Myelodysplastic Syndrome
    • Myelofibrosis
    • Myeloproliferative Disease
    • Polycythemia Vera
    • Waldenstrom's Macroglobulinemia

    Primary Location

    • Herbert Irving Pavilion

      161 Fort Washington Ave
      Garden Level
      New York, NY 10032
      Phone:
      (646) 317-5077
      Appointment:
      (212) 305-5098

    Biographical Detail

    Academic Appointments

    • Assistant Professor of Medicine at CUMC

    Education And Training

      Education & Training

    • University of Virginia School of Medicine
    • MD, University of Virginia School of Medicine
    • Residency: Stonybrook University Hospital
    • Fellowship: Memorial Sloan-Kettering Cancer Center

    Gender

    Male

    Languages Spoken

    • English

    Positions

    Leukemia and Hematology Services, Memorial Sloan-Kettering Cancer Center, 1993-2012

    Committee/societies Council Memberships

    American Society of Hematology

    American Society of Clinical Oncology

    American Society of Physicians

    Hairy Cell Leukemia Consortium

    Mastocytosis Society

    Erdheim-Chester Disease Global Alliance

  2. We have developed a comprehensive clinical trials portfolio to identify new treatment options for patients with all stages of chronic myeloid leukemias, the myeloproliferative neoplasms and myelodysplastic syndrome. For chronic myeloid leukemia, we have clinical trials that also explore the possibility that treatment might be stopped in patients who achieve a high quality response. Our trials include the use of currently-approved drugs administered in novel ways and new agents, either alone or combined with proven therapies, in an effort to improve responses and/or reduce side effects. We are also partnering with research laboratories, both academic and in the pharmaceutical industry to identify new treatments, particularly in the very rare diseases that I treat that do not have proven therapies. Our clinical trials are used as an adjunct to existing treatments in order to provide patients with treatment options that fit best with the patient’s specific needs.

    I have also had a long interest in laboratory research focused on the biology of blood cancers. Together with my colleagues we are developing a test that may help identify which patients with chronic blood cancers are more likely to need treatment sooner. We also believe that we can exploit the differences in the biology of the cells in patients with more aggressive disease to identify new targets that will lead to better treatments.

    Clinical Trials (Current/Completed)

    http://clinicaltrials.gov/ct2/show/NCT01744665

    http://clinicaltrials.gov/ct2/show/NCT01784068

    http://clinicaltrials.gov/ct2/show/NCT01584531

    http://clinicaltrials.gov/ct2/show/NCT01928537

    http://clinicaltrials.gov/ct2/show/NCT01632904

    Research Information

  3. publications

    Selected Bibliography (of more than 50):

     

    Heaney ML, Vera JC, Raines MA, Golde DW:  Membrane-associated and soluble granulocyte/macrophage-colony-stimulating factor receptor a subunits are independently regulated in HL-60 cells.  Proc Natl Acad Sci USA 92:2365-2369, 1995

    Heaney ML, Golde DW:  Myelodysplasia.  New Engl J Med 340:1649-1659, 1999

    Niu L, Golde DW, Vera JC, Heaney ML:  Kinetic resolution of two mechanisms for high-affinity granulocyte-macrophage colony-stimulating factor binding to its receptor.  Blood  94:3748-3753, 1999

    Golde DW, Caggiano J, Heaney ML: Cladribine misdosing in hairy cell leukemia: a cause for apparent response failure.  Leukemia Lymphoma 43: 365-367, 2002

    Brown WE, Coakley FV, Heaney ML: CT of renal involvement by Rosai Dorfman Disease.  Abdominal Imaging 27: 214-216, 2002

    O’Connor OA, Heaney ML, Schwartz L, Richardson S, Willim R, MacGregor-Cortelli B, Curly T, Moskowitz C, Portlock C, Horwitz S, Zelenetz AD, Frankel S, Richon V, Marks P, Kelly WK.: Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies. J Clin Oncol 24: 166-173, 2006

    Paoluzzi L, Gonen M, Gardner JR, Mastrella J, Yang D, Holmlund J, Sorensen M, Leopold L, Manova K, Marcucci G, Heaney ML, O’Connor OA.  Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma. Blood 111:5350-8, 2008

    Heaney ML, Gardner JR, Karasavvas N, Golde DW, Scheinberg DA, Smith EA, O’Connor OA. Vitamin C antagonizes the cytotoxic effects of antineoplastic drugs. Cancer Res. 68:8031-8. 2008

    Koppikar K, Abdel-Wahab O, Hedvat C, Marubayashi S, Patel J, Goel A, Kucine N, Gardner JR, Combs AP, Vaddi K, Haley PJ, Burn TC, Rupar M, Bromberg JF, Heaney ML, de Stanchina E, Fridman JS, Levine RL. Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis. Blood 115:2919-27, 2010

    Mascarenhas J, Heaney ML, Najfeld V, Hexner E, Abdel-Wahab O, Rampal R, Ravandi F, Petersen B, Roboz G, Feldman E, Podoltsev N, Douer D, Levine R, Tallman M, Hoffman R. Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): Formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium. Leuk Res 36:500-4, 201

    Heaney ML. Inside Blood: Saving orphans: BRAF targeting of histiocytosis. Blood 121:1487-88, 2013

    Mallikaratchy P, Gardner J, Nordstrøm LU, Veomett NJ, McDevitt MR, Heaney ML, Scheinberg DA. A self-assembling short oligonucleotide duplex suitable for pretargeting. Nucleic Acid Ther 23: 289-99, 2013

    Soriano G, Heaney M.  Polycythemia vera and essential thrombocythemia: new developments in biology with therapeutic implications. Curr Opin  Hematol 20:169-75, 2013

    For a complete list of publications, please visit PubMed.gov