Quan V. (Donny) Hoang, MD, PhD
- Department of Ophthalmology
Quan V. Donny Hoang, M.D., Ph.D. is a nationally recognized physician and researcher specializing in the treatment of retinal disorders.
Dr. Hoang went to Northwestern University where he received a triple major with honors in Chemistry, Biology and Integrated Science. He then received his joint M.D. and Ph.D. in Neuroscience from the University of Illinois at Chicago where he was awarded the 2005 Grass Fellowship at the Marine Biological Laboratory and the 2006 Top Thesis award in the Life Sciences before completing his residency at the University of Illinois Eye and Ear Infirmary under Drs. William Mieler and Dmitri Azar. Dr. Hoang completed in fellowship in vitreo-retinal surgery at Columbia University Medical Center and the Vitreous, Retina, Macula Consultants of New York (VRMNY) under the joint direction of Dr. Stanley Chang and Dr. Lawrence Yannuzzi.
Dr. Hoang is a well-published physician scientist with over 20 first-authored peer-reviewed articles and over 30 abstracts. His current research projects focus on pathologic myopia, specifically clinical studies employing multimodal imaging to better assess myopic staphyloma progression as well as pre-clinical studies utilizing scleral collagen crosslinking as a novel therapeutic intervention.
Honors and Awards
- 2013-2016 Louis V. Gerstner Jr. Scholar (in support of clinician-scientists)
- 2013-2015 K12 Clinical Translational Sciences Mentored Career Development Award
- 2010 Illinois Eye and Ear Infirmary Top Resident Research Award
- 2009 Top Resident Research Award- Chicago Ophthalmological Society Beem-Fisher Award
- 2009 Illinois Society for the Prevention of Blindness Research Grant
- 2006 Outstanding Thesis Award in the Life Sciences, UIC Graduate College
- 2005 Grass Fellowship in the Neurosciences, Marine Biological Laboratory
- 2004 National Eye Institute fellowship program: Fundamental Issues in Vision Research
- 2004 Top Speaker, UTMB National Student Research Forum, Anatomy/Neuroscience
- 2003 Ruth L. Kirschstein National Research Service Award
- 2003 Society for Neuroscience/ Eli Lily Graduate Student Award
- 1996 Northwestern University Undergraduate Research Grant
- 1996 Shemin Undergraduate Research Fellowship
- 1993 National Academy of Science, Space & Technology Scholarship
Quan V. (Donny) Hoang, MD, PhD
is accepting new patients.
Call (212) 305-9535 for appointments.
Areas of Expertise
- Vitreoretinal Disorder
- Retina and Vitreous Surgery
- Macular Disorder
Edward S. Harkness Eye Institute635 West 165th StreetNew York, NY 10032
- (212) 305-9535
- (212) 342-5235
Eastside Ophthalmology880 Third Avenue
Floor: 2New York, NY 10022
- (212) 305-9535
- (212) 342-5293
- Assistant Professor of Ophthalmology at CUMC
Education And Training
- University of Illinois College of Medicine
- Internship: Northwestern University Hospital
- Fellowship: Columbia University / Vitreous Retina Macula Consultants of NY
- Residency: Eye and Ear Infirmary-University of IL
Education & Training
The Hoang laboratory implements a translational research program consisting of:
- identifying the type of patients with extreme near-sightedness (pathologic myopia) that are at the greatest risk of permanent vision loss,
- discovering novel treatments to stunt myopia progression to avoid the vision-threatening changes, and eventually
- applying these novel treatments to at-risk patients.
Pathologic myopia, or extreme nearsightedness, is a leading cause of blindness and health disparity worldwide. It has been estimated that up to 2.3 billion people are myopic globally and the numbers are rising. Presently, myopia affects at least 33 percent of adults in the United States and as high as 80 percent in Southeast Asia. Although minimal levels of near-sightedness are considered a minor inconvenience, high (pathologic) myopia can lead to irreversible vision loss. Myopia is often due to excessive eye elongation. Pathologic myopia occurs at extreme levels of lifelong, progressive eye elongation and subsequent eye wall (sclera) thinning, which allows for localized outpouchings (called staphyloma). It is a breakdown in the structural integrity of the collagen component in the eye wall that may underlie myopic progression and precede irreversible vision loss.
The first step in identifying pathologic myopia patients at greatest risk of vision loss is to perform multimodal imaging and in vivo biomechanical testing to establish a quantitative measure of the stiffness of the posterior eye wall. This goal is achieved by a combination of imaging modalities such as optical coherence tomography, ultrasonongraphy and magnetic resonance imaging with the eye at rest as well as during biomechanical stress-strain experiments.
Concurrently, novel therapeutic approaches are explored in preclinical studies in animal models where non-light-activated chemicals are applied in vivo to crosslink the collagen in eye walls to act as a mortar, stiffening the wall and stunting eye elongation (and progression of nearsightedness). These two approaches together will arrive at an in vivo quantitative measure to identify the type of pathologic myopia patients that would most benefit from our novel treatment, once animal trials are completed.
Quan Wen, M.D. (Associate Research Scientist)
Jamie A. Leong (Graduate student)
Jonathan Tang (Medical student- NIH Ruth L. Kirschstein T35 National Research Service Award)
Julie Weinstein (Medical student- Senior Scholarly Projects Program)
Elona Gavazi M.D. (3rd year ophthalmology resident)
- Novel approaches toward the diagnosis and treatment of pathologic myopia.
- Scleral collagen-crosslinking
- Multimodal imaging (OCT, US, MRI) of staphylomatous pathologic myopia
- In vivo measurement of scleral elastic modulus
Edward S. Harkness Eye Institute635 West 165th Street
7th Floor, Room 711
New York, NY 10032
- (212) 305-0899
- Hoang QV, Cunningham ET, Sorenson JA and Freund KB. The “Pitchfork Sign” – A Distinctive Optical Coherence Tomography Finding in Inflammatory Choroidal Neovascularization. Retina. 2013 Mar 19. [Epub ahead of print]
- Chang S, Gregory-Roberts E, Laud KL, Park S and Hoang QV. The Charles L. Schepens Lecture: Is Double Peeling Necessary in Vitrectomy for Macular Pucker? JAMA Ophthalmol. 2013 Apr 1;131(4):525-30.
- Hoang QV, Gallego-Pinazo R and Yannuzzi LA. Long-term Follow-up of Acute Zonal Occult Outer Retinopathy. Retina. 2013. (in press)
- Hoang QV, Tsuang AJ, Gelman R, Mendonca LS, DellaTorre KE, Jung JJ and Freund KB. Clinical Predictors of Sustained Intraocular Pressure Elevation from Intravitreal Anti-VEGF Therapy for Neovascular AMD. Retina. 2013 Jan;33(1):179-87.
- Hoang QV, Savinsky-Strauss D and Freund KB. Imaging in the Diagnosis and Management of Acute Idiopathic Maculopathy. Int Ophthalmol Clin. 2012 Fall;52(4):263-8.
- Hoang QV, Mendonca LS, DellaTorre KE, Jung JJ, Tsuang AJ and Freund KB. Multivariate Analysis of Clinical Predictors of Sustained Intraocular Pressure Elevation from Intravitreal Anti-VEGF Therapy for Neovascular AMD. Ophthalmology. 2012 Feb;119(2):321-6.
- Hoang QV, Freund KB, Klancnik JM, Sorenson JA, Cunningham ET and Yannuzzi LA. Focal Retinal Phlebitis. Retina. 2012 Jan;32(1):120-6.
- Hoang QV, Chau FY, Blair MP and Shapiro MJ. Nasal Dragging of the Retina and Temporal Arcades in Retinopathy of Prematurity. Retinal Cases and Brief Reports. Spring 2011:5(2):165-166.
- Hoang QV, Chau FY, Shahidi M and Lim JI. Central Macular Splaying and Outer Retinal Thinning in Asymptomatic Sickle Cell Patients by Spectral Domain Optical Coherence Tomography. Am J Ophth. 2011 Jun;151(6):990-994.e1.
- Hoang QV, Blair MP, Rahmani B, Galasso JM and Shapiro MJ. Multiple Retinal Holes and Peripheral Nonperfusion in Muscle-Eye-Brain Disease. Arch Ophthalmol. 2011 Mar;129(3):373-5.
- Hoang QV, Chau FY, Shahidi M, Miller MT and Blair MP. Macular Thinning Associated with Unilateral Optic Nerve Hypoplasia. Ophthalmic Surg Lasers Imaging. 2011 Feb 1;42:e6-9.
- Hoang QV, Simon DM and Goldstein DA. Approach to Recurrent CMV Disease and Antiviral Resistance. Graefes Arch Clin Exp Ophthalmol. 2011 Jan;249(1):149.
- Hoang QV, Blair MP and Shapiro MJ. Anomalous Retinal Vasculature in a Patient with a History of Aortic Coarctation. Retinal Cases and Brief Reports. Winter 2011:5(1):79-81.
- Hoang QV, Kiernan DF, Chau FY, Shapiro MJ and Blair MP. Fluorescein Angiography of Recurrent Retinopathy of Prematurity after Initial Intravitreal Bevacizumab. Arch Ophthalmol. 2010 Aug;128(8):1080-1.
- Hoang QV, Simon DM, Kumar GN, Oh F and Goldstein DA. Recurrent CMV Retinitis in a Non-HIV Patient with Drug-Resistent CMV. Graefes Arch Clin Exp Ophthalmol. 2010 May;248(5):737-40.
- Hoang QV, Qian H and Ripps H. Functional Analysis of Hemichannels and Gap-Junctional Channels Formed by Connexins 43 and 46. Molecular Vision. 2010 Jul 15;16:1343-52.
- Bajic D, Hoang QV, Nakajima S, and Nakajima Y. Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects. J Neurosci Methods. 2004; 132:177-184.
- Hoang QV, Zhao P, Nakajima S, and Nakajima Y. Orexin (Hypocretin) Effects on Constitutively Active Inward Rectifier K+ Channels in Cultured Nucleus Basalis Neurons. J Neurophysiology. 2004; 92:3183-91.
- Hoang QV, Bajic D, Yanagisawa M, Nakajima S, and Nakajima Y. Effects of Orexin (Hypocretin) on GIRK Channels. J Neurophysiology. 2003; 90:693-702.
- Hoang QV, Linsenmeier RA, Chung CK, and Curcio CA. Photoreceptor Inner Segments in Monkey and Human Retina: Mitochondrial Density, Optics, and Regional Variation. Visual Neuroscience. 2002;19:395-407. (cover)