1. Wendy K. Chung, MD, PhD

    • Department of Pediatrics
      Division of Pediatric Clinical Genetics
    Headshot

    Dr. Chung is a board certified clinical geneticist with a PhD in molecular genetics. She received her MD from Cornell University and her PhD from The Rockefeller University. She is director of the clinical genetics program at Columbia University, a co-director of the molecular genetics diagnostics lab, and heads a research laboratory in the division of molecular genetics investigating the genetic bases for a variety of Mendelian and complex traits.

    CUMC crown logoWendy K. Chung, MD, PhD
    is accepting new patients.
    Call (212) 305-5890 for appointments.

    Provider Information

    One of America's Top Doctors
    One of America's Top Doctors.
    Rated one of New York Magazine's Best Doctors
    Rated One of New York Magazine's
    Best Doctors.

    Board Certifications

    • Clinical Genetics (MD)
    • Clinical Molecular Genetics

    Clinical Expertise

    • Cancer Care
    • Inborn Metabolism Disorder
    • Cleft Palate With Cleft Lip
    • Congenital Heart Disease
    • Seizures
    • Cancer Genetics
    • Arrhythmia
    • Genetic Counseling
    • Mental Retardation
    • Pediatric Seizures
    • Abdominal Hernia
    • Pancreatic Cancer
    • Pediatric Mental Retardation
    • Pulmonary Hypertension

    Hospital Affiliations

    • NewYork-Presbyterian/Columbia

    Primary Location

    • Russ Berrie Medical Science Pavilion

      1150 St. Nicholas Avenue
      New York, NY 10032
      For new and current patient appointments, call:
      (212) 305-6731
      Fax:
      (212) 305-9058

    Insurance Programs

    Please contact the provider’s office directly to verify that your particular insurance is accepted.
    • Aetna [EPO, HMO, Medicare, NY Signature, POS, PPO, Signature Administrators, Student Health]
    • Affinity [Access (Exchange), Essential Plan, Medicaid Managed Care, Medicare Managed Care]
    • Amida Care
    • Cigna [EPO, Great West, HMO, POS, PPO]
    • Emblem/HIP [ConnectiCare, EPO, Essential Plan, HMO, Medicaid Managed Care, Medicare Managed Care, POS, PPO, Select Care (Exchange), Vytra]
    • Empire Blue Cross Blue Shield [Blue Priority, EPO, HMO, Medicare (Mediblue), NYP Employee Plan, Pathway (Exchange), POS, PPO]
    • Empire Blue Cross Blue Shield HealthPlus [Child/Family Health Plus, Essential Plan, Medicaid Managed Care]
    • Fidelis Care [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]
    • GHI [EPO, PPO]
    • Healthfirst [Child/Family Health Plus, Medicaid Managed Care, Medicare Managed Care]
    • Local 1199
    • MagnaCare
    • Medicaid [CT, NJ, NY]
    • Medicare [Medicare]
    • Multiplan
    • Oxford Health Plans [Freedom, Liberty, Medicare Managed Care]
    • POMCO
    • UnitedHealthcare [Columbia University Employee Plan, Compass (Exchange), EPO, HMO, Medicaid (Community Plan), Medicare Managed Care, POS, PPO, The Empire Plan (NYSHIP)]
    • VNSNY CHOICE [SelectHealth]

    Biographical Detail

    Academic Appointments

    • Associate Professor of Pediatrics (in Medicine)

    Education And Training

      Education & Training

    • Weill Cornell Medical College
    • Internship: NewYork-Presbyterian Hospital/Columbia University Medical Center
    • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
    • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

    Gender

    Female

    Languages Spoken

    • Spanish
  2. Dr. Wendy Chung is a human geneticist whose current research activities include efforts to identify genes and their relevant allelic variants related to the development of congenital diaphragmatic hernia, congenital cardiac malformations including heterotaxy, hypoplastic left heart syndrome, cardiac septal defects, cardiomyopathies, and congenital and acquired long QT syndromes. 

    In genetic studies of arrhythmias, the patient's personal history of inciting triggers, T wave morphology on ECG, and the family history are used to choose candidate genes for linkage analysis when possible and mutation identification in one of the genes/loci identified to date in long QT syndrome. 
     
    In genetic studies of hypertrophic cardiomyopathy, the patient's history of age of onset, other associated medical problems, and family history are used to choose candidate genes for mutation identification. In studies of congenital heart disease and congenital diaphragmatic hernias, the probands are studied by comparative genomic hybridization to detect genomic alterations such as insertions or deletions on a genome wide basis. Then candidate genes are selected based upon their roles in embryonic diaphragmatic and cardiac development and screened for mutations by high throughput sequencing. Genotype-phenotype correlations are then made by comparing clinical features and outcome based on genetic etiology of a disease. Another area of research includes the identification of genes related to obesity and type 2 diabetes in mice and humans. 
     
    Dr. Chung and associates have mapped and cloned naturally occurring spontaneous mutations in the mouse causing both monogenic forms of obesity (tubby and diabetes) as well as a suppressor of obesity called mahoganoid. We have also identified 25 quantitative trait loci (QTLs) that interact with monogenic forms of obesity to produce varying degrees of diabetes susceptibility. We have made congenic lines for most of these QTLs and have identified a QTL for diabetes call Lisch-like. 
     
    In parallel with these rodent studies, Dr. Chung is a participant in large ongoing human genetic studies to identify the genetic susceptibility to obesity and diabetes in humans. In collaboration with investigators around the world, we have access to over 100,000 human subjects phenotyped for adiposity and have developed high throughput methods for sequencing large genomic regions for regulatory variants and have identified novel contiguous gene deletions associated with syndromic forms of obesity. 
     
    We are also studying the molecular mechanism by which the genes FTO/FTM recently identified through large genome wide association studies cause increased adiposity. We have identified novel mutations in the Wolframin gene causing a rare autosomal recessive form of diabetes mellitus and characterized the uniparental disomy of chromosome 6 in neonates with transient neonatal diabetes. In addition, families with maturity onset diabetes of the young (MODY) and have identified a rare neonatal complication of hypoglycemia associated with MODY. 
     
    Dr. Chung also provide the molecular genetics core services for the Obesity Research Center, Diabetes and Endocrine Research Center, Pediatric Neuromuscular Clinical Research Network studying spinal muscular atrophy, and the Pediatric Heart Network.

    Research Information

    Grants/Contracts

    • COLUMBIA GENIE (GENOMIC INTEGRATION WITH EHR) (Federal Gov)

      Sep 1 2015 - May 31 2019

      FUNCTIONAL IMAGING AND EATING BEHAVIOR AMONG FTO GENOTYPES IN PRE-OBESES CHILDREN (Federal Gov)

      Sep 18 2013 - Aug 31 2018

      CENTER FOR RESEARCH ON ETHICAL, LEGAL AND SOCIAL IMPLICATIONS OF PSYCHIATRIC, NEUROLOGIC AND BEHAVIORAL GENETICS (Federal Gov)

      May 3 2013 - May 31 2018

      DIABETES AND ENDOCRINOLOGY RESEARCH CENTER (Federal Gov)

      Mar 15 2013 - Jan 31 2018

      BREAST CANCER FAMILY REGISTRY COHORT - NY COHORT (Federal Gov)

      Sep 12 2012 - Aug 31 2017

      PRENATAL CYTOGENETIC DIAGNOSIS BY ARRAY-BASED COPY NUMBER ANALYSES: FOLLOW-UP (Federal Gov)

      Jun 8 2007 - May 31 2017

      GENES, ENVIRONMENT AND BREAST CANCER RISK: THE 15 YEAR FOLLOW-UP OF THE PROF-SC (TERRY/HOPPER) (Federal Gov)

      Jul 1 2011 - Apr 30 2017

      LEGACY: A COHORT OF YOUTH IN FAMILIES FROM THE BREAST CANCER FAMILY REGISTRY (Federal Gov)

      Jan 10 2011 - Dec 31 2016

      NEWBORN SCREENING FOR SPINAL MUSCULAR ATROPHY (Private)

      Jul 1 2014 - Jun 30 2016

      THE GOALS AND PRACTICES FOR NEXT GENERATION PRENATAL TESTING (Federal Gov)

      Aug 10 2015 - May 31 2016

      PSYCHOSOCIAL IMPACT OF GENETICS IN EPILEPSY (Federal Gov)

      Apr 1 2012 - Mar 31 2016

      NEW YORK NUTRITION OBESITY RESEARCH CENTER (Federal Gov)

      Dec 1 1996 - Mar 31 2016

      MOLECULAR APPROACHES TO GENE IDENTIFICATION IN CONGENITAL HEART DISEASE (Federal Gov)

      Sep 30 2009 - Jan 31 2016

      WHOLE EXOME SEQUENCING AS A DISCOVERY AND DIAGNOSTIC TOOL IN FAMILIAL DIABETES EMILY BREIDBART, M.D. (Private)

      Jun 1 2014 - Dec 31 2015

      RETURNING GENETIC RESEARCH PANEL RESULTS FOR BREAST CANCER SUSCEPTIBILITY (Federal Gov)

      Sep 9 2014 - Aug 31 2015

      IMPACT OF RETURN OF INCIDENTAL GENETIC TEST RESULTS TO RESEARCH PARTICIPANTS IN THE GENOMIC ERA (Federal Gov)

      Sep 23 2011 - Aug 31 2015

      STEERING COMMITTEE CHAIR FOR THE PEDIATRIC CARDIAC GENOMICS CONSORTIUM (PCGC) (Federal Gov)

      Oct 1 2010 - Jul 31 2015

      PEDIATRIC NEUROMUSCULAR CLINICAL RESEARCH NETWORK FOR SMA (Private)

      Jul 1 2012 - Jun 30 2015

      NYORC MOLECULAR GENETICS/MOLECULAR BIOLOGY CORE (Federal Gov)

      Jun 10 2011 - Dec 31 2014

      MOLECULAR GENETIC ANALYSIS OF HUMAN OBESITY (Federal Gov)

      Dec 1 2008 - Nov 30 2014

      CHALLENGES OF INFORMED CONSENT IN RETURN OF DATA FROM GENOMIC RESEARCH (Federal Gov)

      Sep 23 2011 - Aug 31 2014

      IMPACT OF RETURN OF INCIDENTAL GENETIC TEST RESULTS TO RESEARCH PARTICIPANTS IN THE GENOMIC ERA (Federal Gov)

      Sep 23 2011 - Aug 31 2014

      IDENTIFICATION OF NOVEL GENES FOR CONGENITAL DIAPHRAGMATIC HERNIA (Federal Gov)

      Sep 29 2008 - Jun 30 2014

      CENTER FOR ELSI RESEARCH ON PSYCHIATRIC, NEUROLOGIC, AND BEHAVIORAL GENETICS (Federal Gov)

      Jun 1 2010 - Apr 30 2014

      CONFIRMATION CORE THE CONGENITAL HEART DISEASE GENETIC NETWORK STUDY (CHD GENES) FOR THE PEDIATRIC CARDIAC GENOMICS CONSORTIUM (PCGC) (Federal Gov)

      Jun 1 2012 - Feb 28 2014

      EXOME SEQUENCING TO IDENTIFY NOVEL CAUSES OF INFANTILE HYPERTROPHIC CARDIOMYOPATHY (Private)

      Mar 1 2011 - Dec 31 2013

      SIMONS VARIATION IN INDIVIDUALS PROJECT (SIMONS VIP) (Private)

      Aug 1 2011 - Jul 31 2013

      HORMONAL, METABOLIC AND SIGNALING INTERACTIONS IN PAH (Federal Gov)

      Sep 1 2012 - Jun 30 2013

      SC CHAIR - CONGENITAL HEART DISEASE GENETIC NETWORK STUDY (CHD GENES) (Federal Gov)

      Jun 1 2012 - May 31 2013

      CHANGE: CHANGING HEALTH CARE AND NURSING THROUGH GENETICS (Private)

      Sep 1 2009 - Feb 28 2013

      IDENTIFICATION OF NOVEL BREAST CANCER SUSCEPTIBILITY GENES (Private)

      Aug 1 2007 - Jul 31 2011

      CHEMOPREVENTION OF BASAL CELL CARCINOMAS WITH TAZAROTENE (Federal Gov)

      Jul 1 2007 - Jun 30 2011

      LYSOSOMAL STORAGE DISORDERS EDUCATION GRANT (Private)

      Jan 1 2008 - Dec 31 2009

      EFFECTS OF THE HISTONE DEACETYLASE INHIBITOR LBH589 ON IN VI TRO TRANSCRIPTION AND TRANSLATION OF SUR (Private)

      Oct 15 2007 - Apr 14 2009

  3. publications

    For a complete list of publications, please visit PubMed.gov