1. Wendy K. Chung, MD, PhD

    • Department of Pediatrics
      Division of Pediatric Clinical Genetics
    Headshot

    Dr. Chung is a board certified clinical geneticist with a PhD in molecular genetics. She received her MD from Cornell University and her PhD from The Rockefeller University. She is director of the clinical genetics program at Columbia University, a co-director of the molecular genetics diagnostics lab, and heads a research laboratory in the division of molecular genetics investigating the genetic bases for a variety of Mendelian and complex traits.

    CUMC crown logoWendy K. Chung, MD, PhD
    is accepting new patients.
    Call (212) 305-5890 for appointments.

    Provider Information

    One of America's Top Doctors
    One of America's Top Doctors.
    Rated one of New York Magazine's Best Doctors
    Rated One of New York Magazine's
    Best Doctors.

    Board Certifications

    • Clinical Genetics (MD)
    • Clinical Molecular Genetics

    Areas of Expertise

    • Inborn Metabolism Disorder
    • Mental Retardation
    • Cleft Palate With Cleft Lip
    • Pancreatic Cancer
    • Congenital Heart Disease
    • Arrhythmia
    • Pediatric Mental Retardation
    • Cancer Genetics
    • Pulmonary Hypertension
    • Genetic Counseling
    • Seizures
    • Abdominal Hernia
    • Pediatric Seizures

    Primary Location

    • Russ Berrie Medical Science Pavilion

      1150 Street Nicholas Avenue
      New York, NY 10032
      Appointment:
      (212) 305-5890
      Fax:
      (212) 305-9058

    Insurance Programs

    Please contact the provider’s office directly to verify that your particular insurance is accepted.
    • Aetna [PPO] - Open
    • Aetna [HMO] - Open
    • Aetna [Medicare] - Open
    • Affinity [Medicare] - Open
    • Affinity [HMO] - Open
    • Affinity [Medicaid] - Open
    • CIGNA [POS] - Open
    • CIGNA [PPO] - Open
    • CIGNA [HMO] - Open
    • CIGNA [Columbia University Employee Plan] - Open
    • CIGNA [Medicare] - Open
    • Empire Blue Cross Blue Shield [HMO] - Open
    • Empire Blue Cross Blue Shield [PPO] - Open
    • Empire Blue Cross Blue Shield [EPO] - Open
    • Empire Blue Cross Blue Shield [Mediblue (Senior)] - Open
    • Health First [HMO] - Open
    • Health First - Open
    • Health First [Medicaid] - Open
    • Health Insurance Plan of NY (HIP) [HMO] - Open
    • Health Insurance Plan of NY (HIP) [POS] - Open
    • Health Insurance Plan of NY (HIP) [Medicare] - Open
    • Health Insurance Plan of NY (HIP) [PPO] - Open
    • Health Net (PHS) [POS] - Open
    • Health Net (PHS) [PPO] - Open
    • Health Net (PHS) [HMO] - Open
    • Health Plus - Amerigroup [HMO]
    • Local 1199 [Union] - Open
    • Medicare [Medicare] - Open
    • Neighborhood Health Providers [Medicaid] - Open
    • Oxford Health Plans [Community Medicare] - Open
    • Oxford Health Plans [Medicare Advantage] - Open
    • United Healthcare [EPO] - Open
    • United Healthcare [Columbia University Employee Plan] - Open
    • United Healthcare [HMO] - Open
    • United Healthcare [POS] - Open
    • United Healthcare [PPO] - Open

    Biographical Detail

    Academic Appointments

    • Associate Professor of Pediatrics

    Education And Training

      Education & Training

    • Weill Cornell Medical College
    • Internship: NewYork-Presbyterian Hospital/Columbia University Medical Center
    • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
    • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

    Gender

    Female

    Languages Spoken

    • Spanish
  2. Dr. Wendy Chung is a human geneticist whose current research activities include efforts to identify genes and their relevant allelic variants related to the development of congenital diaphragmatic hernia, congenital cardiac malformations including heterotaxy, hypoplastic left heart syndrome, cardiac septal defects, cardiomyopathies, and congenital and acquired long QT syndromes. 

    In genetic studies of arrhythmias, the patient's personal history of inciting triggers, T wave morphology on ECG, and the family history are used to choose candidate genes for linkage analysis when possible and mutation identification in one of the genes/loci identified to date in long QT syndrome. 
     
    In genetic studies of hypertrophic cardiomyopathy, the patient's history of age of onset, other associated medical problems, and family history are used to choose candidate genes for mutation identification. In studies of congenital heart disease and congenital diaphragmatic hernias, the probands are studied by comparative genomic hybridization to detect genomic alterations such as insertions or deletions on a genome wide basis. Then candidate genes are selected based upon their roles in embryonic diaphragmatic and cardiac development and screened for mutations by high throughput sequencing. Genotype-phenotype correlations are then made by comparing clinical features and outcome based on genetic etiology of a disease. Another area of research includes the identification of genes related to obesity and type 2 diabetes in mice and humans. 
     
    Dr. Chung and associates have mapped and cloned naturally occurring spontaneous mutations in the mouse causing both monogenic forms of obesity (tubby and diabetes) as well as a suppressor of obesity called mahoganoid. We have also identified 25 quantitative trait loci (QTLs) that interact with monogenic forms of obesity to produce varying degrees of diabetes susceptibility. We have made congenic lines for most of these QTLs and have identified a QTL for diabetes call Lisch-like. 
     
    In parallel with these rodent studies, Dr. Chung is a participant in large ongoing human genetic studies to identify the genetic susceptibility to obesity and diabetes in humans. In collaboration with investigators around the world, we have access to over 100,000 human subjects phenotyped for adiposity and have developed high throughput methods for sequencing large genomic regions for regulatory variants and have identified novel contiguous gene deletions associated with syndromic forms of obesity. 
     
    We are also studying the molecular mechanism by which the genes FTO/FTM recently identified through large genome wide association studies cause increased adiposity. We have identified novel mutations in the Wolframin gene causing a rare autosomal recessive form of diabetes mellitus and characterized the uniparental disomy of chromosome 6 in neonates with transient neonatal diabetes. In addition, families with maturity onset diabetes of the young (MODY) and have identified a rare neonatal complication of hypoglycemia associated with MODY. 
     
    Dr. Chung also provide the molecular genetics core services for the Obesity Research Center, Diabetes and Endocrine Research Center, Pediatric Neuromuscular Clinical Research Network studying spinal muscular atrophy, and the Pediatric Heart Network.

    Research Information

    NIH Grants

  3. publications

    For a complete list of publications, please visit PubMed.gov