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Adam D. Griesemer, MD

Board Certifications: 
Surgery
Expertise in: 
Transplant Hepatology
Accepting New Patients
Treats Children
Profile Headshot

Appointments

Phone Appointments

New and Existing Patients: 
(212) 305-9691

myColumbiaDoctors

For existing patients, login to make an appointment, view documentation or contact your care provider.

Credentials & Experience

Board Certifications

  • Surgery

Clinical Expertise

  • Transplant Hepatology
  • Pediatric Transplant Hepatology
  • Pediatric Transplant Surgery
  • Portal Hypertension
  • Surgery
  • Minimally Invasive Surgery
  • Shunts
  • Living Donor Liver Surgery

Education & Training

  • University of Missouri Columbia School of Medicine
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center

Honors & Awards

  • AASLD Career Development Award in Liver Transplantation, 2015
  • Forde Award for Research, Columbia University, 2013
  • Department of Surgery's Chairman's Research Award, Columbia University College of Physicians and Surgeons, 2013
  • Louis V. Gerstner, Jr. Scholar – Research Award, Columbia University College of Physicians and Surgeons, 2013
  • Blakemore Prize - Best Resident Research Award, Columbia University College of Physicians and Surgeons, 2011
  • Blakemore Award - Best Resident Research Award, Columbia University College of Physicians and Surgeons, 2009
  • American Society of Transplantation Young Investigator Award, Transplantation Biology Research Center, Harvard Medical School, 2008
  • International Xenotransplantation Travel Grant, Transplantation Biology Research Center, Harvard Medical School, 2007
  • American Society of Transplantation/JDRF Research Fellowship Award, Transplantation Biology Research Center, Harvard Medical School, 2005
  • Alpha Omega Alpha, University of Missouri-Columbia School of Medicine, 2003
  • Marion DeWeese Award for Excellence in General Surgery, University of Missouri-Columbia School of Medicine, 2003
  • Donald Silver Award for Excellence in Vascular Surgery, University of Missouri-Columbia School of Medicine, 2003

About Adam Griesemer

Academic Titles

  • Assistant Professor of Surgery at CUMC

Administrative Positions

  • Director, Large Animal Xenotransplantation Laboratory, Columbia Center for Translational Immunology

Committee/Societies/Council Memberships

  • American Association for the Study of Liver Diseases, 2013- present
  • American Society of Transplant Surgeons, 2010- present
  • The Transplantation Society, 2007- present
  • International Xenotransplantation Association, 2007-present
  • American Society of Transplantation, 2005-present

Hospital Affiliations

  • NewYork-Presbyterian/Morgan Stanley Children's Hospital
  • NewYork-Presbyterian/Columbia

Gender

  • Male

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Affinity

  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Amida Care

  • Special Needs Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Medicare

  • Traditional Medicare (NY)

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

POMCO

  • POMCO

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • Medicare Managed Care
  • SelectHealth

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Contact & Locations

1
622 West 168th Street
New York, New York 10032
Phone: (212) 305-9691
Primary

Research

Allogeneic Studies

My laboratory is investigating the ability of ex-vivo expanded Tregs to enhance bone marrow engraftment and extend the duration of mixed chimerism. The induction of durable mixed chimerism without graft-versus-host disease should in turn lead to life-long donor-specific tolerance to any co-transplanted cells (islets) or solid organs (heart, liver, lung) from the donor. We are also collaborating with other investigators at the CCTI to study the ability of amnion-derived multipotent progenitor cells to enhance bone marrow engraftment in translational models as an alternate, and potentially synergistic, strategy to induce durable mixed chimerism.

We are also investigating the ability to translate the induction protocol that induces tolerance to simultaneously co-transplanted bone marrow and kidney grafts (despite only transient mixed chimerism developing) to combined bone marrow and liver grafts. In particular, we are investigating 1) the role of donor and recipient memory cells in mediating host-versus-graft and graft-versus-host responses; and 2) the role that inflammatory cytokines, particularly in the portal system, play in priming inflammatory and tolerogenic cellular responses.

The future goals of the laboratory include collaborating with the Chen lab in testing the ability of durable mixed chimerism to induce tolerance to organs that do not facilitate tolerance with the transient mixed chimerism approach, such as islets. We also plan to test the ability of modulating the T cell memory responses and the inflammatory environment induced after liver transplant to reliably induce rapid tolerance after liver transplants.

Xenogeneic Studies

The development of Gal-knockout swine removed the most significant target of natural antibodies from the surface of pig cells. However, low levels of non-Gal antibodies represent a barrier to long-term solid organ xenograft survival and xenogeneic bone marrow engraftment. Since pharmacological interventions have been unsuccessful in decreasing natural antibody levels, my lab is investigating the efficacy of Treg therapy in reducing anti-swine antibodies and facilitating tolerance induction to xenotransplants.

Current investigations include:

1. Studies on the optimal method of stimulating Tregs during expansion to generate donor-specific Tregs

2. Suppression of xenogeneic natural antibodies by donor-specific Tregs in preclinical models

3. Augmentation of xenogeneic chimerism using donor-specific Tregs

The future goals of the laboratory are to utilize donor-specific Tregs to control the natural anti-swine antibody response in translational swine-to-humanized mice and swine-to-nonhuman primate models. This in turn will facilitate the induction of xenogeneic chimerism that is expected to result in robust tolerance to donor solid organ transplants.

Research Interests

  • Use of Tregs to control natural antibody responses and facilitate xenogeneic bone marrow engraftment
  • Xenogeneic tolerance induction via mixed chimerism and thymus transplant
  • Allogeneic tolerance induction
  • Control of humoral rejection
  • Small for Size Syndrome after Living Donor Liver Transplantation

Grants

REGULATORY T CELLS TO PROMOTE MIXED CHIMERISM FOR TOLERANCE TO ISLETS ANDKIDNEYS FROM DECEASED AND LIVING DONORS (Federal Gov)

Aug 18 2017 - Jul 31 2022

DEVELOPMENT OF LUNG T CELL RESPONSES IN INFANT RESPIRATORY IMMUNITY (Federal Gov)

Aug 1 2017 - Jul 31 2022

HUMAN ANTI-VIRAL IMMUNE RESPONSES IN TISSUES AND CIRCULATION (Federal Gov)

Jan 1 2017 - Dec 31 2021

A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Federal Gov)

Aug 1 2017 - Jul 31 2021

ROBUST ALLOGRAFT TOLERANCE IN NON-HUMAN PRIMATES (Federal Gov)

Jul 1 2015 - Mar 31 2020

A TOLERANCE APPROACH TO XENOTRANSPLANTATION (Private)

Aug 6 2015 - Aug 5 2018

IMPROVING ENGRAFTMENT AND SURVIVAL OF PIG ISLET XENOGRAFTS THROUGH TRANSGENIC EXPRESSION OF HUMAN CD47 (Private)

Mar 1 2017 - Feb 28 2018

TOLERANCE TO VASCULARIZED ALLOGRAFTS IN MINISWINE (Federal Gov)

Apr 1 1991 - Jan 31 2018

ESTABLISHMENT OF DONOR CHIMERISM USING ALLOGENEIC BONE MARROW WITH AMP CELL CO-INFUSION (Federal Gov)

Aug 15 2015 - Aug 14 2017

IMMUNE RESPONSE TO COMBINED LIVER AND BONE MARROW TRANSPLANT OR TOLERANCE IN NHP (Federal Gov)

Aug 19 2016 - Jul 31 2017

2016 ASTS PRESIDENTIAL STUDENT MENTOR GRANT (Private)

Jul 1 2016 - Jun 30 2017

CAREER DEVELOPMENT AWARD IN LIVER TRANSPLANTATION IN MEMORY OF THE UNIVERSITY OF MICHIGAN TRANSPLANT TEAM (Private)

Jul 1 2015 - Jun 30 2017

Selected Publications

  • Thome J, Bickham K, Ohmura Y, Kubota M, Matsuoka N, Gordon C, Granot T, Griesemer A, Lerner H, Kato T, and Farber D. Compartmentalization of infant T-cell differentiation and regulation in human tissues. Nature Medicine. Accepted - In Press
  • Soubrane O, Rougemont O, Kim K, Samstein B, Mamode N, Boillot O, Troisi R, Scatton O, Cauchy F, Lee S, Griesemer A, Ahmed Z, Clavien P, and Cherqui D. Laparoscopic Living Donor Left Lateral Sectionectomy: a New Standard Practice for Donor Hepatectomy. Annals of Surgery. Accepted – In Press.
  • Parekh M, Kluger M, Griesemer A, and Bentley-Hibbert S. Regenerative Liver Surgeries: The alphabet soup of emerging techniques. American Journal of Roentgenology. Accepted – In Press
  • Weiner J, Griesemer A, Island E, Lobritto S, Martinez M, Selvaggi G, Lefkowitch J, Velasco M, Tryphonopoulos P, Emond J, Tzakis A, Kato T. Long-Term Outcomes of Auxiliary Partial Orthotopic Liver Transplantation in Pre-Adolescent Children with Fulminant Hepatic Failure. Liver Transpl. 2015 Oct 19. PMID: 26479577
  • Matsuoka N, Weiner JI, Griesemer AD, Samstein BB, Zhao Y, et al. Ex Vivo Pancreaticoduodenectomy and Liver Autotransplantation for Pancreatic Head Tumor with Extensive Involvement of the Hepatoduodenal Ligament. Liver Transplantation. 2015; PMID: 26289503
  • Samstein B, Griesemer A, Cherqui D, Mansour T, Pisa J, et al. Fully laparoscopic left-sided donor hepatectomy is safe and associated with shorter hospital stay and earlier return to work: A comparative study. Liver Transplantation. 2015; 21(6):768-73.PMID: 25789460
  • Weiner J, Duran-Struuck R, Zitsman J, Buhler L, Sondermeijer H, McMurchy A, Levings MK, Sykes M, Griesemer A. Restimulation after cryopreservation and thawing preserves the phenotype and function of expanded baboon regulatory T cells. Transplantation Direct. 2015 February; 1(1):1-7.
  • Wang H, Griesemer AD, Parsons RF, Graham JA, Emond JC, Samstein B. Delayed Gastric Emptying after Living donor Hepatectomy for Liver Transplantation. Case Reports in Transplantation. 2014. PMID: 25610698 PMCID: PMC4291134
  • Halazun KJ, Patzer RE, Rana AA, Verna EC, Griesemer AD, Parsons RF, Samstein B, Guarrera JV, Kato T, Brown RS Jr, Emond JC. Standing the test of time: Outcomes of a decade of prioritizing patients with HCC, results of the UNOS natural geographic experiment. Hepatology. 2014 Jun 20. PMID: 24954365
  • Weiner J, Wu J, Martinez M, Lobritto S, Ovchinsky N, Rohde C, Griesemer A, Kato T. The use of bi-planar tissue expanders to augment abdominal domain in a pediatric intestinal transplant recipient. Pediatr Transplant. 2014 Aug;18(5):E174-9. PMID: 25041331
  • Samstein B, Cherqui D, Guarrera J, Griesemer A, Halazun KJ, Kato T, Emond JE. Totally laparoscopic full left hepatectomy for living donor liver transplantation in adolescents and adults. Am J Transplant. 2013 Sept: 13: 2462–2466.
  • Yamada K, Hirakata A, Tchipashvili V, Shimizu A, Iwaki H, Griesemer A, Moran S, Sachs DH Composite Islet-Kidneys From Single Baboon Donors Cure Diabetes Across Fully Allogenic Barriers. Am J Transplant. 2011 Dec;11(12):2603-12. PMID:21929644.
  • Hirakata A, Okumi M, Griesemer AD, Shimizu A, Nobori S, Tena A, Moran S, Arn S, Boyd RL, Sachs DH, Yamada K. Reversal of age-related thymic involution by an LHRH agonist in miniature swine. Transpl Immunol. 2010 Oct;24(1):76-81. PMID: 20692342.
  • Griesemer AD, Sorenson EC, Hardy MA. The Role of the Thymus in Tolerance. Transplantation. 2010 Sep 15;90(5):465-74. PMID: 20555306.
  • Griesemer A, Widmann W, Forde KA, Hardy MA. John Jones, MD. Pioneer, Patriot and Founder of American Surgery. World J Surg. 2010 Apr;34(4):605-9. PMID: 20012608.
  • Weiner J, Scalea J, Ishikawa Y, Okumi M, Griesemer A, Hirakata A, Etter J, Gillon B, Moran S, Shimizu A, Yamada K, Sachs DH. Tolerogenicity of Donor Major Histocompatibility complex-matched Skin Grafts in Previously Tolerant Massachusetts General Hospital Miniature Swine. Transplantation. 2012 Dec 27;94(12):1192-9. PMID:23269447.
  • Tena A, Vallabhajosyula P, Hawley RJ, Griesemer A, Yamada K, Sachs DH. Quantification of Baboon Thymopoiesis in Porcine Thymokidney Xenografts by the Signal-Joining T-Cell Receptor Excision Circle Assay. Transplantation. 2011 Mar 27;91(6):639-44. PMID: 21285918.
  • Griesemer A, Liang F, Hirakata A, Hirsh E, Lo D, Okumi M, Sykes M, Yamada K, Huang CA, Sachs DH. Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons. Xenotransplantation. 2010 Jul;17(4):300-12. PMID: 20723202.
  • IshikawaY, Hirakata A, Griesemer A, Etter J, Moran S, Weiner J, Shimizu A, Yamada K. Tolerance and long-lasting peripheral chimerism following allogeneic intestinal transplantation in MGH miniature swine. Transplantation. 2010 Feb 27;89(4):417-26. PMID: 20177343.
  • Griesemer A, Hirakata A, Shimizu A, Moran A, Tena A, Iwaki H, Ishikawa Y, Schule P, Arn J, Robson S, Fishman J, Sykes M, Sachs D, Yamada K. Results of Gal-Knockout porcine thymokidney xenografts. Am J Transplant. 2009 Dec;9(12):2669-78. PMID: 19845583.
  • Griesemer A, Yamada K, and Sachs DH. “Strategies for Immune Tolerance Induction in Islet Transplantation and Xenotransplantation” Chapter in Islets: Biology, Immunology, and Clinical Transplantation Dr. Fouad Kandeel, Editor, In Press. ISBN-10: 0387795774.
  • Griesemer AD, Okumi M, Shimizu A, Moran S, Ishikawa Y, Iorio J, Arn JS, Yamada K. Upregulation of CD59: potential mechanism of accommodation in a large animal model. Transplantation. 2009 May 15;87(9):1308-17. PMID: 19424030.
  • Knosalla C, Yazawa K, Behdad A, Bodyak N, Shang H, Bühler L, Houser S, Gollackner B, Griesemer A, Schmitt-Knosalla I, Schuurman HJ, Awwad M, Sachs DH, Cooper DK, Yamada K, Usheva A, Robson SC. Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation. Am J Transplant. 2009 May;9(5):1006-16. PMID: 19422330.
  • Mii A, Shimizu A, Masuda Y, Fujita E, Aki K, Ishizaki M, Sato S, Griesemer A, Fukuda Y. Current status and issues of C1q nephropathy. Clin Exp Nephrol. Clin Exp Nephrol. 2009 Aug;13(4):263-74. PMID: 19373520.
  • Issa NC, Wilkinson RA, Griesemer A, Cooper DK, Yamada K, Sachs DH, Fishman JA. Absence of replication of porcine endogenous retrovirus and porcine lymphotropic herpesvirus type 1 with prolonged pig cell microchimerism after pig-to-baboon xenotransplantation. Journal of Virology. 2008 Dec;82(24):12441-8. PMID: 18829759.
  • Griesemer AD, Lamattina JC, Okumi M, Etter JD, Shimizu A, Sachs DH, Yamada K. Linked suppression across an MHC-mismatched barrier in a miniature swine kidney transplantation model. Journal of Immunology. 2008 Sep 15;181(6):4027-36. PMID: 18768858.
  • Oku M, Okumi M, Sahara H, Hirakata A, Onoe T, Griesemer AD, Yamada K. Porcine CFSE mixed lymphocyte reaction and PKH-26 cell-mediated lympholysis assays. Transplant Immunology. 2008 Nov;20(1-2):78-82. PMID: 18718865.
  • Okumi M, Fishbein JM, Griesemer A, Gianello PR, Hirakata A, Nobori S, Moran S, Samelson-Jones E, Shimizu A, Sachs DH, Yamada K. Breaking tolerance to kidney allografts in miniature swine I. Role of persistence of antigen and indirect recognition in the maintenance of tolerance to renal allografts. Transplantation 2008 Jan; 85(2): 270-208. PMID: 18212633
  • Vallabhajosyula P, Griesemer A, Yamada K, Sachs DH. Vascularized composite islet-kidney transplantation in a miniature swine model. Cell Biochemistry and Biophysics 2007 48:2-3, 201. PMID: 17709890.
  • Yamada K, Griesemer A, Sykes M, Sachs DH. Cotransplantation of vascularized thymus and kidney from GalT-KO pigs to baboons. Xenotransplantation. 2007 Mar;14(2):186-9.
  • Nobori S, Shimizu A, Okumi M, Samelson-Jones E, Griesemer A, Hirakata A, Sachs DH, Yamada K. Thymic rejuvenation and the induction of tolerance by adult thymic grafts. Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19081-6. PMID: 17148614.
  • Wong BS, Yamada K, Okumi M, Weiner J, O'Malley PE, Tseng YL, Dor FJ, Cooper DK, Saidman SL, Griesemer A, Sachs DH. Allosensitization does not increase the risk of xenoreactivity to alpha1,3-galactosyltransferase gene-knockout miniature swine in patients on transplantation waiting lists. Transplantation. 2006 Aug 15;82(3):314-9. PMID: 16906027.
  • Yamada K, Griesemer A, Okumi M. Pigs as xenogeneic donors. Transplantation Reviews, 2005 June, 19(3) pp. 164-177.
  • Griesemer A. Emond J. Laparoscopy for cystic parasitic and non-parasitic disease of the liver. Invited expert comment in: Gagner M, Assalia A, and M Schein, eds. Controversies in Laparoscopic Surgery, 2004.
  • Losanoff JE, Richman BW, Foerst JR, Griesemer AD, Mundis GM, Jones JW. Nonspecific ulcers of the colon. Endoscopy. 2003 Jun;35(6):521-5. PMID: 12783352
  • Fuchimoto Y. Huang CA. Yamada K. Gleit ZL. Kitamura H. Griesemer A. Scheier-Dolberg R. Melendy E. White-Scharf ME. Sachs DH. Induction of kidney allograft tolerance through mixed chimerism in miniature swine. Transplantation Proceedings. 33(1-2):77, 2001 Feb-Mar. PMID: 11266710.
  • Fuchimoto Y. Huang CA. Gleit ZL. Kitamura H. Griesemer A. Melendy E. Scheier-Dolberg R. White-Scharf ME. Sachs DH. Mixed chimerism using a nonmyelosuppressive regimen in miniature swine. Transplantation Proceedings. 33(1-2):118-9, 2001 Feb-Mar. PMID: 11266736.
  • Huang CA. Fuchimoto Y. Gleit ZL. Ericsson T. Griesemer A., Scheier-Dolberg R. Melendy E. Kitamura H. Fishman JA. Ferry JA. Harris NL. Patience C. Sachs DH. Posttransplantation lymphoproliferative disease in miniature swine after allogeneic hematopoietic cell transplantation: similarity to human PTLD and association with a porcine gammaherpesvirus. Blood. 97(5):1467-73, 2001 Mar 1. PMID: 11222395.
  • Mumm JS. Schroeter EH. Saxena MT., Griesemer A. ,Tian X. Pan DJ. Ray WJ. Kopan R. A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Molecular Cell. 5(2):197-206, 2000 Feb. PMID: 10882062.