Close mobile menu×
Close mobile menu

Ali Gharavi, MD

Board Certifications: 
Nephrology
Not Accepting New Patients
Profile Headshot

Appointments

myColumbiaDoctors

For existing patients, login to make an appointment, view documentation or contact your care provider.

Credentials & Experience

Board Certifications

  • Nephrology

Clinical Expertise

  • Chronic Glomerular Diseases

Education & Training

  • George Washington University School of Medicine
  • Residency: Mount Sinai Medical Center
  • Fellowship: Mount Sinai Medical Center

Honors & Awards

  • 1997 First Prize Fellow research award, New York /New Jersey National Kidney Foundation
  • 1997 Recognition Award for Young Physicians, American Society of Hypertension
  • 2000 Young Investigator Award, Emerald Foundation
  • 2003 Irving Clinical Scholar Award, Columbia University
  • 2004 Judson Daland Prize for Outstanding Clinical Investigation, American Philosophical Society
  • 2005 National Kidney Foundation Clinical Scientist Award
  • 2006 Zambetti fellowship, Columbia University 2009 Ewig Clinical Education Award, Columbia University
  • 2010 American Society of Clinical Investigation

About Ali Gharavi

My objective is to bring personalized genomic nephrology from the laboratory into patient care.

Dr. Ali Gharavi, a leading kidney disease researcher, is chief of the division of nephrology at NewYork-Presbyterian/Columbia University Medical Center. Dr. Gharavi, also an associate professor of medicine at Columbia University College of Physicians and Surgeons and director of its renal physiology and pathophysiology course, joined NewYork-Presbyterian/Columbia in 2003.

“My objective is to bring personalized genomic nephrology from the laboratory into patient care,” says Dr. Gharavi. “Owing to the recent progress in genomic technologies, we now have the opportunity to make a precise genetic diagnosis for many patients and individualize care based on the specific molecular mechanism of disease.” The principal investigator on four current projects funded by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health and the New York State Empire Clinical Research Investigator Program, Dr. Gharavi has specific interests in the genetics of kidney disease, including IgA nephropathy and congenital abnormalities of the kidney and urinary tract. IgA nephropathy is a kidney disorder that occurs when IgA—an antibody that helps the body fight infections—settles in the kidneys, which can cause the kidneys to leak blood and sometimes protein in the urine. It can eventually lead to kidney failure.

Dr. Gharavi’s work has identified multiple regions of the genome that confer risk of IgA nephropathy and has yielded novel insight into the mechanisms of kidney injury underlying the condition. His other research includes the genetic causes of congenital abnormalities of the kidney and the urinary tract, the most common cause of kidney failure in children, for which he has described several new genetic mutations. Dr. Gharavi is a member of the American Society of Nephrology, International Society of Nephrology, and American Society of Human Genetics. He is the author of 63 peer-reviewed publications in high-impact journals including Nature, Nature Genetics and the New England Journal of Medicine, sits on the editorial boards of the Journal of the American Society of Nephrology and Kidney International, and has been a guest editor of PLoS Genetics. He was a recipient of the Judson Daland Prize for Outstanding Clinical Investigation from the American Philosophical Society and the National Kidney Foundation Clinical Scientist Award and was elected to the American Society of Clinical Investigation.

After receiving his medical degree from George Washington University, Dr. Gharavi completed his residency at Mount Sinai Medical Center and fellowships in hypertension and nephrology, also at Mount Sinai. He then completed a postdoctoral fellowship in genetics at Yale University School of Medicine. He previously held academic appointments at Yale University School of Medicine and Mount Sinai School of Medicine and hospital appointments at Mount Sinai Hospital.

Academic Titles

  • Professor of Medicine

Administrative Positions

  • Chief, Division of Nephrology

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Gender

  • Male

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Indemnity
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Affinity

  • Access (Exchange)
  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Amida Care

  • Special Needs Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • HMO
  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Medicare

  • Traditional Medicare (NY)

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

POMCO

  • POMCO

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • SelectHealth

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Contact & Locations

1
1150 St. Nicholas Avenue
New York, New York 10032
Phone:
(212) 305-3273
Fax:
(212) 305-4981
Primary

Research

My research is focused on the molecular genetics of kidney diseases, particularly glomerular and developmental disorders. The long term objective is to identify specific genes and dysregulated pathways underlying kidney disorders in order to facilitate the development of new diagnostic tools and rational therapies. Learn more at the Gharavi Lab Web site.

Research Interests

  • Congenital anomalies of the kidney and urogenital tract
  • IgA Nephropathy
  • Glomerulosclerosis

Grants

COLUMBIA/CORNELL/HARLEM HOSPITAL PRECISION MEDICINE INITIATIVE HPO (Federal Gov)

Jul 6 2016 - Dec 31 2021

PRECISION MEDICINE RESEARCH IN NEPHROLOGY (Federal Gov)

Jul 1 2016 - Jun 30 2021

GENETICS OF HUMAN RENAL HYPODYSPLASIA (Federal Gov)

Apr 1 2008 - Dec 31 2019

MULTISPECIES, INTEGRATIVE GWAS FOR FOCAL SEGMENTAL GLOMERULOSCLEROSIS (Federal Gov)

Aug 15 2016 - Aug 14 2019

THE GENETIC ORIGINS AND COMPLICATIONS OF URINARY TRACT ABNORMALITIES (Federal Gov)

Sep 24 2014 - Jul 31 2019

ELUCIDATING IGA NEPHROPATHY THROUGH GENETIC STUDIES OF IGA1 GLYCOSYLATION (Federal Gov)

Sep 15 2014 - Jun 30 2019

ANCESTRY, GENETIC RISK AND HEALTH DISPARITIES IN GLOMERULAR DISEASES (Federal Gov)

Jul 10 2014 - Apr 30 2019

CURE GLOMENULOPHROPATHY (Private)

Jan 1 2015 - Dec 31 2018

GENETIC BASIS OF CONGENITAL KIDNEY MALFORMATIONS (Private)

Jul 1 2016 - Jun 30 2018

APTAMER-BASED ARRAYS FOR DETECTION OF PATHOGENIC LGA1 O-GLYCOFORMS IN LGA NEPHROPATHY (Federal Gov)

Apr 1 2016 - May 31 2018

ADVANCING CLINICAL RESEARCH IN PRIMARY GLOMERULAR DISEASES (UM1) (Federal Gov)

Sep 16 2013 - May 31 2018

A GENOMIC MEDICINE PROGRAM FOR CHILDREN AND YOUNG ADULTS WITH CHRONIC KIDNEY DISEASE (Private)

Jan 1 2015 - Dec 31 2016

A PERSONALIZED GENOMIC MEDICINE PROGRAM FOR KIDNEY DISEASES (NY State Gov)

Jan 15 2014 - Jan 14 2016

ASN FELLOWSHIP PROGRAM (Private)

Jul 1 2013 - Jun 30 2015

IDENTIFYING THE EARLIEST EVENTS IN HIV-1 ASSOCIATED NEPHROPATHY VIA GENOME-WIDE DETECTION OF ABERRANT TRANSREGULATION (Federal Gov)

May 1 2010 - Feb 28 2015

ASN STUDENT SCHOLAR GRANT (Private)

Nov 1 2012 - Oct 31 2013

THE PATHOGENESIS OF HIV-ASSOCIATED NEPHROPATHY -PROJECT 3 (Federal Gov)

Jan 1 2011 - Jul 31 2013

NEPHROLOGY FELLOWSHIP AWARD PROGRAM (Private)

Jul 1 2012 - Jun 30 2013

SEARCH FOR RARE STRUCTURAL VARIANTS IN KIDNEY (Private)

Jul 1 2010 - Jun 30 2013

GENETIC AND BIOCHEMICAL STUDIES OF IGA1 GLYCOSYLATION (Federal Gov)

May 1 2011 - Apr 30 2013

GENETIC AND BIOMEDICAL STUDIES OF IGA1 GLYCOSYLATION (Federal Gov)

May 1 2011 - Apr 30 2013

GENETICS AND BIOCHEMICAL STUDIES OF IGA1 GLYCOSYLATION (Federal Gov)

May 1 2011 - Apr 30 2013

A GWAS FOR IGA NEPHROPATHY, THE MOST COMMON FORM OF GLOMERUL ONEPHRITIS (Federal Gov)

Sep 30 2009 - Jul 31 2011

GENETICS OF CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY T RACT (Private)

Jul 1 2010 - Jun 30 2011

GENETIC STUDIES OF HIV-1 ASSOCIATED NEPHROPATHY (Federal Gov)

Jul 1 2005 - Jun 30 2010

Selected Publications

  • Gharavi AG, Yan Y, Scolari F, Schena FP, Frasca GM, Giggheri GM, Cooper K, Amoroso A, Viola BF, Battini G, Caridi G, Canova C, Farhi A, Subramanian V, Nelson-Williams C, Woodford S, Julian BA,Wyatt RJ, Lifton RP. (2000) IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat. Genetics 26:354-7
  • Gharavi AG, Ahmad T, Wong RD, Hooshyar R, Vaughn J, Oller S, Frankel RZ , Bruggeman LA , D'Agati VD , Klotman PE , and Lifton RP. (2004) Mapping a Locus (HIVAN1) for Susceptibility to HIV-1 Associated Nephropathy to Mouse Chromosome 3 Proc Natl Acad Sci U S A. 101:2488-2493
  • Zheng Z, Ott-Schmitt K, Chua S., Foster K A., Frankel R Z., Barasch J, Pavlidis P., D’ Agati VD, Gharavi AG. (2005) A Mendelian Locus on Chromosome 16 Determines Susceptibility to Doxorubicin Nephropathy In The Mouse. Proc Natl Acad Sci U S A. 102:2502-2507
  • Gharavi AG, Moldoveanu Z, Wyatt RJ, Barker CV, Woodford SY, Lifton RP, Mestecky J, Novak J, Julian BA. (2008) Aberrant IgA1 Glycosylation is Inherited in Familial and Sporadic IgA Nephropathy J Am Soc Nephrol 19:1008-14
  • Papeta N, Chan KT, Prakash S, Martino J, Zheng Z, Frankel R, Klotman PE, D’Agati VD, Lifton, RP, Gharavi, AG. (2009) Susceptibility Loci for HIV- Associated Nephropathy encode trans-regulators of Podocyte Gene Expression. J Clin Invest 119:1178-88
  • Papeta N, Zheng Z, Schon EA, Brosel S, Altintas MM, Nasr SH, Reiser J, D'Agati VD, Gharavi AG. (2010) Prkdc participates in mitochondrial genome maintenance and prevents Adriamycin-induced nephropathy in mice. J Clin Invest. 20:4055-64
  • Gharavi AG, Kiryluk K, Choi M, Li Y, Hou P, Xie J, Sanna-Cherchi S, Men CJ, Julian BA, Wyatt RJ, Novak J, He JC, Wang H, Lv J, Zhu L, Wang W, Wang Z, Yasuno K, Gunel M, Mane S, Umlauf S, Tikhonova I, Beerman I, Savoldi S, Magistroni R, Ghiggeri GM, Bodria ( 2011 ) Genome wide association study identifies susceptibility loci for IgA nephropathy. Nat. Genetics 43:321–327
  • Sanna-Cherchi S., Burgess KE, Nees SN, Caridi G, Weng PL, Dagnino M, M, Carrea A, Allegretta MA, Kim HR, Perry BJ, Gigante M, Clark LN, Kisselev S, Cusi D, Loreto Gesualdo L, Allegri L, Scolari F, D’Agati VD, Shapiro LS, Pecoraro C, Palomero T, Ghiggeri G (2011) Exome Sequencing Identifies MYO1E and NEIL1 as Candidate Genes for Human Autosomal Recessive Steroid Resistant Nephrotic Syndrome. Kidney International 80:389-96
  • Kiryluk K, Li Y, Sanna-Cherchi S, Rohanizadegan M, Suzuki H, Eitner, Snyder HJ, Choi M, Hou P, Scolari F, Izzi C, Gigante M, Gesualdo L, Savoldi S, Amoroso A, Cusi D, Zamboli P, Julian BA, Novak J, Wyatt RJ, Mucha K, Perola M, KristianssonK, Magnusson PK, (2012) Geographic Differences in Genetic Susceptibility to IgA Nephropathy: GWAS Replication Study and Geospatial Risk Analysis PloS Genetics 8:e1002765
  • Lugani F, Arora R, Papeta N, Patel A, Zheng Z, Sterken R, Singer RA, Caridi G, Mendelsohn C, Sussel L, Papaioannou VE, Gharavi AG. (2013) A retrotransposon insertion in the 5' regulatory domain of Ptf1a results in ectopic gene expression and multiple congenital defects in Danforth's short tail mouse. PloS Genetics 9:e1003206
  • Sanna-Cherchi S, Sampogna RV, Papeta N, Burgess KE, Nees SN, Perry BJ, Choi M, Bodria M, Liu Y, Weng PL, Lozanovski VJ, Verbitsky M, Lugani F, Sterken R, Paragas N, Caridi G, Carrea A, Dagnino M, Materna-Kiryluk A, Santamaria G, Murtas C, Ristoska-Bojkovs (2013) Mutations in DSTYK and Dominant Urinary Tract Malformations. N Engl J Med. (in press)