Emilio Arteaga-Solis, MD, PhD

Dr. Arteaga-Solis has spent most of his research career elucidating the role of extracellular proteins in development and disease processes. His initial work focused on understanding the function of the extracellular microfibillar proteins fibrillin 1 and 2, which are mutated in Marfan and Beals syndromes, respectively. He was the first to demonstrate that fibrillin 2 played a regulatory role in limb development and bone growth. This work led to a new paradigm, now well accepted, that the fibrillins regulate signaling molecules during development and tissue maintenance. He has published various reviews and book chapters on Marfan syndrome and related disorders. More recently he was involved in studying the chondrodysplasia and lung defect in a mouse model of multi sulfatase deficiency. He has demonstrated that the state of proteoglycans desulfation affects fibroblast growth factor signaling during endochondral ossification and transforming growth factor b during lung alveolar formation. His research experience and clinical interest has led to the development of a new research project where he will study the linkage between obesity and asthma.