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Danielle Trief, MD, MSc

Board Certifications: 
Expertise in: 
Laser Surgery, Corneal/External Diseases, Cataract Surgery
Accepting New Patients
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Phone Appointments

New and Existing Patients: 
(212) 305-9535


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Credentials & Experience

Board Certifications

  • Ophthalmology

Clinical Expertise

  • Laser Surgery
  • Corneal/External Diseases
  • Cataract Surgery
  • Corneal Disorders
  • Cornea and External Eye Disease
  • Cornea Transplant
  • Cataract
  • Cataract Surgery
  • Pterygium
  • Refractive Eye Surgery
  • Laser Vision Correction
  • Anterior Segment Surgery

Education & Training

  • MD, Columbia University College of Physicians and Surgeons
  • MSc, Neuroscience, Oxford University (United Kingdom)
  • Internship: Lankenau Hospital
  • Residency: Massachusetts Eye & Ear Infirmary
  • Fellowship: New York Eye & Ear Infirmary

Honors & Awards

2018, 2017 Super Doctors

2013 ASCRS Foundation Resident Excellence Award

2013 ASCRS Council of 100

2013 Resident Ambassador to AAO mid-year forum

2010 Glasgow-Rubin Achievement Award

2005-2006 The Thouron Fellowship

2005 Penn Student Agency Award of Merit

About Danielle Trief

Danielle Trief, MD, MSc - ColumbiaDoctors Ophthalmologist

Danielle Trief MD MSc, is an assistant professor of Ophthalmology at Columbia University Medical Center. Dr. Trief specializes in the medical and surgical management of cornea, pediatric cornea, cataract, and external diseases. Her surgical expertise includes corneal transplantation, cataract surgery, secondary intraocular lens placement, anterior segment reconstruction, and laser vision correction. Dr. Trief runs a monthly clinic dedicated to children with corneal diseases. 

Dr. Trief received her undergraduate degree from the University of Pennsylvania, where she graduated Summa Cum Laude and was elected Phi Beta Kappa. She was awarded a Thoroun Fellowship to pursue a Masters of Neuroscience at Oxford University. At Oxford, she published on neuroplasticity following stroke and graduated with honors. She completed medical school at Columbia University College of Physicians and Surgeons, where she was elected into the Alpha Omega Alpha medical honor society. She completed her ophthalmology residency at Harvard Medical School/Massachusetts Eye and Ear infirmary and subsequently pursued a cornea and refractive surgery fellowship at the New York Eye and Ear Infirmary.

Dr. Trief has published numerous articles, book chapters, and teaching videos on adult and pediatric cornea. She has been invited to speak nationally and internationally on her research topics. She is dedicated to the well being of her patients and understands the role that vision can play in everyday life. She grew up volunteering at her mother’s preschool, a school for visually impaired and blind children. Dr. Trief is an active member of the American Academy of Ophthalmology (AAO), the Cornea Society, Association for Research in Vision and Ophthalmology (ARVO), and the American Society of Cataract & Refractive Surgery (ASCRS).

Academic Titles

  • Assistant Professor of Ophthalmology at CUMC

Hospital Affiliations

  • NewYork-Presbyterian/Columbia


  • Female

Insurance Accepted


  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health


  • EPO
  • Great West
  • HMO
  • POS
  • PPO


  • HMO
  • Medicare Managed Care
  • PPO


  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Local 1199

  • Local 1199


  • MagnaCare


  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care


  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • HMO
  • Medicare Managed Care
  • POS
  • PPO

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Contact & Locations

250 West 64th Street
New York, New York 10023
(212) 305-9535
(212) 342-3932
880 Third Avenue
New York, New York 10022
(212) 305-9535
(212) 201-4129
635 West 165th Street
New York, New York 10032
(212) 305-9535
(212) 342-5293


Selected Publications

Trief D, Gray ST, Jakobiec FA, Durand ML, Fay A, Freitag SK, Lefebvre DR, Holbrook E, Bleier B, Sadow P, Rashid A, Chabra N, Yoon MK. Outcomes of invasive fungal disease of the sinus and orbit. British Journal of Ophthalmology. 2015 Jun 25

Jakobiec FA, Rose MF, Trief D, Stagner AM, Kim I, Gragoudas ES. Immunohistochemical investigations of adult intraocular medulloepithelioma. Clinical Experimental Ophthalmology May-Jun;43(4):379-85

Jakobiec FA, Trief D, Rashid A, Rose MF, Minckler D, Vanderveen D, Mukai S. New insights into the development of infantile intraocular medulloepithelioma. American Journal of Ophthalmology 2014 Dec;158(6): 1275-1296

Trief D, Adebona O, Turalba A, Shah A. Pediatric traumatic hyphema; International Ophthalmology Clinics. Fall 2013. 53(4):43-57

Lo K, Trief D, Kohanim S, Chodosh J. Role of amniotic membrane transplant in acute chemical injury. International Ophthalmology Clinics; Fall 2013. Fall;53(4):33-41

Yonekawa Y, Orbach DB, Trief D, Shah AS, Vanderveen DK. Intra-arterial chemotherapy for n Group C retinoblastoma with adjacent high-flow infantile hemangioma. Ophthalmic Surgical, Lasers and Imaging Retina 2013 Sep-Oct; 44(5):490-2

Adebona O, Trief D, Shah AS. Pediatric traumatic hyphema, a 9-year retrospective review. In Progress.

Braunstein AL, Trief D, Wang N, Chang S, Tsang SH. Vitamin A deficiency in New York City. The Lancet 2010; 376(9737):267.

O'Shea J, Johansen-Berg H, Trief D, Rushworth M. Functionally-specific reorganization in human premotor cortex. Neuron 2007; 54(3): 479-90.

Maxwell, CR, Ehrlichman, RS, Liang, Y, Trief, D, Kanes, SJ, Karp, J, Siegel SJ. Ketamine produces lasting disruptions in encoding of sensory stimuli. J Pharmacol Exp Ther. 2006; 316(1): 315-24.

Siegel SJ, Maxwell CR, Majumdar S, Trief DF, Lerman C, Gur RE, Kanes SJ, Liang Y. Monoamine reuptake inhibition and nicotine receptor antagonism reduce attenuation and amplitude of auditory evoked potentials. Neuroscience 2005; 133(3): 729-38.

Trief, D. Models of altruism as applied to human blood and organ donation. Penn Science 2004; 2(2).