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Kurenai Tanji, MD

Board Certifications: 
Neuropathology, Anatomic Pathology
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Credentials & Experience

Board Certifications

  • Neuropathology
  • Anatomic Pathology

Specialties

Education & Training

  • Kinki University School of Medicine, Japan
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center

About Kurenai Tanji

Dr. Tanji obtained the medical degree and training in pathology at Kinki University School of Medicine, Osaka, Japan, and joined Department of Neurology, Columbia University as a post-doctoral research fellow in 1991, studying muscle biology in the fields of Duchenne muscular dystrophy and mitochondrial encephalomyopathy.

In 2000, she moved to Department of Pathology & Cell Biology, Columbia University, to repeat the pathology residency in the United States, followed by the neuropathology fellowship, and joined the pathology faculty in 2004. She has been actively involved in the clinical service of neuropathology, especially in the neuromuscular pathology, collaborative research works in muscular dystrophy and mitochondrial disease, and medical and post-graduate education. She has been serving as the director of the Laboratory of Neuromuscular Pathology, Department of Pathology & Cell Biology, since 2008.

Email: kt8@cumc.columbia.edu

Academic Titles

  • Professor of Pathology and Cell Biology (in Neurology)

Committee/Societies/Council Memberships

American Association of Neuropathologists

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Languages

  • Japanese

Gender

  • Female

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • HMO
  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

POMCO

  • POMCO

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Research

Research Interests

  • Molecular Pathology of Mitochondrial Disease

Grants

MITOCHONDRIAL ENCEPHALOMYOPATHIES: APPROACHES TO TREATMENT (Federal Gov)

Sep 30 2014 - May 31 2019

MITOCHONDRIAL ENCEPHALOMYOPATHIES AND MENTAL RETARDATION (Federal Gov)

Dec 1 1996 - Feb 29 2016

MOLECULAR PATHOGENESIS AND TREATMENT OF MNGIE (Federal Gov)

Apr 1 2010 - Jan 31 2016

SPINAL MUSCULAR ATROPHY (SMA): DISEASE PHENOTYPE AND MECHANISMS (Federal Gov)

Aug 1 2009 - Aug 31 2013

Selected Publications

Sancho S, Moraes CT, Tanji K, DiMauro S, Miranda AF. Structural and functional abnormalities associated with high levels of partially deleted mitochondrial DNAs in somatic cell hybrids. Somat. Cell Mol. Genet. 1992;18:431-442.

Sancho S, Mongini T, Tanji K, Tapscolt SJ, Walker WF, Weintraub H, Miller DA, Miranda AF. Dystrophin analysis after forced activation of myogenesis in amniocytes, chorionic villi, and fibroblasts: a new diagnostic method for Duchenne muscular dystrophy. N. Eng. J. Med. 1993;329:915-920.

Tanji K, Sancho S, Miranda AF. Innervation of MyoD converted human amniocytes and fibroblasts by fetal rodent spinal cord neurons. Neuromusc. Disord.1994;4:317-324.

Bohlega S, Tanji K, Santorelli FM, Hirano M, DiMauro S. Multiple mitochondrial DNA deletions associated with autosomal recessive ophthalmoplegia and severe cardiomyopathy. Neurology 1996;46:1329-1334.

Santorelli FM, Sciacco M, Tanji K, Shanske S, Vu TH, Golzi V, Griggs RC, Mendell JR, Hays AP, Bertorini TE, Pestronk A, Bonilla E, DiMauro S. Multiple mitochondrial DNA deletions in sporadic inclusion-body myositis. A study of 56 patients. Ann. Neurol. 1996;39:789-795.

Tanji K, Vu TH, Schon EA, DiMauro S, Bonilla E. Kearns-Sayre syndrome: Unusual pattern of expression of subunits of the respiratory chain in the cerebellar system. Ann. Neurol. 1999;45:377-383.

Tanji K, DiMauro S, Bonilla E. Disconnection of cerebellar Purkinje cells in Kearns-Sayre syndrome. J. Neurol. Sci. 1999;166:64-70.

Andreu AL, Hanna MG, Reichman H, Bruno C, Penn AS, Tanji K, Pallotti F, Iwata S, Bonilla E, Lach B, Morgan-Hughes J, DiMauro S. Exercise intolerance and mutations in the cytochrome b gene of mitochondrial DNA. N. Eng. J. Med. 1999;341:1037-1044.

Papadopoulou LC, Sue CM, Davidson M, Tanji K, Nishino I, Sadlock J, Selby J, Moira Glerum D, Van Coster R, Lyon G, Scalais E, Lebel R, Kaplan P, Shanske S, De Vivo D, Bonilla E, Hirano M, DiMauro S, Schon EA. Fatal infantile cardioencephalopathy with cytochrome c oxidase (COX) deficiency and mutations in SCO2, a human COX assembly gene. Nature Genet. 1999;23:333-337.

Sue CM, Karadimas C, Checcarelli N, Tanji K, Papadopoulou LC, Palotti F, Shanske S, Hirano M, De Vivo DC, Van Coster R, Kaplan P, Bonilla E, DiMauro S. Differential features of patients with mutations in two COX assembly genes, SURF-1 and SCO2. Ann. Neurol. 2000;47:589-595.

Tanji K, Bonilla E. Neuropathologic aspects of cytochrome c oxidase deficiency. Brain Pathol. 2000;10:422-430.

Tanji K, Schon EA, DiMauro S, Bonilla E. Kearns-Sayre syndrome: oncocytic transformation of choroid plexus epithelium. J. Neurol. Sci. 2000;178:29-36.

Nishino I, Fu J, Tanji K, Yamada T. Shimojo S, Koori T, Mora M, Riggs JE, Oh SJ, Koga Y, Sue CM, Murakami N, Shanske S, Byrne E. Bonilla E, Nonaka I, DiMauro S, Hirano M. Primary LAMP-2 deficiency causes vacuolar cardiomyopathy, myopathy and mental retardation (Danon's disease). Nature 2000;406:906-910.

Vu TH, Tanji K, Holve SA, Bonilla E, Sokol RJ, Snyder RD, Fiore S. Deutsch GH, DiMauro S, De Vivo D. Navajo neurohepathopathy: A mitochondrial DNA depletion syndrome? Hepatology 2001;34(1):116-120.

Tanji K, Gamez J, Cervera C, Mearin F, Ortega A, Torre J, Montoya J, Andreu AL, DiMauro S, Bonilla E. The A8344G mutation in mitochondrial DNA associated with stroke-like episodes and gastrointestinal dysfunction. Acta Neuropathol. 2003;105:69-75.

Tanji K, Bhagat G, Monzon BS, Bonilla E, Lefkowitch JH. Oncocytic hepatocytes; Are they a consequence of mitochondrial dysfunction. Liver Int. 2003;13:1-7.

Karadimas CL, Vu TH, Holve SA, Quinzii C, Tanji K, Bonilla E, DeVivo DC, Dimauro S, Hirano M. Navajo neurohepatopathy is caused by a mutation in the MPV17 gene. Am. J. Hum. Genet. 2006;79:544-548.

Quinzii CM, Vu TH, Min C, Tanji K, Barral A, Grewal R, Kattah A, Camano P, Otaegui D, Blake DM, Wilhelmsen KC, Rowland LP, Hays AP, Bonilla E, Hirano M. X-linked dominant scapuloperoneal myopathy is due to a mutation in the gene encoding four and an half LIM protein 1 (FHL1). Am. J. Hum. Genet. 2008; 82(1):208-213.

Akman H, Dorado B, Lopez LC, Garcia-Cazorla A, Vila MR, Tanabe LM, Dauer WT, Bonilla E, Tanji K, Hirano M. Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenace. Hum Mol Genet 2008; 17(16): 2433 – 2440.

Tanji K, Bonilla E. Light microscopic methods to visualize mitochondria on tissue sections. Methods 2008; 46(4): 274 – 280.

Lopez LC, Akman HO, Garcia-Cazorla A, Dorado B, Marti R, Nishino I, Tadesse S, Pizzorno G, Shungu D, Tanji K, Hirano M. Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice. Hum Mol Genet 2009; 18(4): 714-722.

Emmanuele V, Garcia-Cazorla A, Huang HB, Coku J, Dorado B, DiMauro S, Tanji K. Decreased hippocampal expression of calbindin D28KD and cognitive impairment in MELAS. J Neurol Sci 2012; 317:29-34.

Garone C, Rubio JC Calvo SE, Naini A, Tanji K, DiMauro S, Mootha VK, Hirano M. MPV 17 mutations causing adult-onset multisystemic disorder with multiple mitochondrial DNA deletions. Arch Neurol 2012; 69(12): 1648-1651.

Melia M, Kubota A, Ortolano S, Vilchez JJ, Gamez J, Tanji K, Bonilla E, Palenzuela Lluis, Fernandez-Cadenas I, Pristoupilava A, Garcia-Arumi E, Andreu LA, Navaro C, Hirano M and Marti R. Limb-girdle muscular sytrophy1F (LGMD1F) is casued by a microdeletion in the transporin-3 gene. Brain 2013; 136(Pt5):1508-17.

Shin JY, Mendez-Lopez I, Wang Y, Hays AP, Tanji K, Lefkowitch JH, Shultz PC, Worman HJ, Dauer WT. Lamina-associated Polypeptide-1 Interacts with the Muscular Dystrophy Protein Emerin and is Essential for Skeletal Muscle Maintenance. Develpmental Cell 2013; 26: 591-603.

Garcia-Diaz B, Garone C, Barca E, Mojahed H, Gutierrez P, Pizzorno G, Tanji K, Arias-Mendoza F  Quinzii CM, Hirano M.   Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency. EMBO Mol Med 2014; 6(8) :1016-1027.

Garcia-Diaz B, Garone C, Barca E, Mojahed H, Gutierrez P, Pizzorno G, Tanji K, Arias-Mendoza F, Quinzii CM, Hirano M.  Deoxynucleoside stress exacerbates the phenotype of a mouse model of mitochondrial neurogastrointestinal encephalopathy. Brain 2014; 137:1337-49.

Emmanuele V, Kubota A, Garone C, Akman HO, Sánchez-Gutiérrez D, Escudero L, Kariya S, Homma S, Tanji K, Hirano M, Quinzzi C. Fhl1 W122S causes loss of protein function and late-onset mild myopathy. Hum Mol Genet 2015; 24(3): 714-726.