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Stephen M. Canfield, MD, PhD

Board Certifications: 
Allergy and Immunology
Accepting New Patients
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Appointments

Phone Appointments

New and Existing Patients: 
(212) 305-1544

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Credentials & Experience

America's Top Doctor
NY Top Doctor

Board Certifications

  • Allergy and Immunology

Clinical Expertise

  • Animal Dander Allergy
  • Drug Allergy
  • Insect Allergy
  • Aspergillosis
  • Allergic Contact Dermatitis
  • Food Allergy
  • Allergic Rhinitis
  • Hypersensitivity Disorder
  • Immunodeficiency Disorder
  • Asthma
  • Atopic Dermatitis
  • Eczema
  • Allergy Evaluation and Treatment

Specialties

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Internship: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center

Honors & Awards

  • 2015 Charles W. Bohmfalk Award for teaching excellence
  • 2011 Ewig Award for Outstanding Clinician Educator
  • 2009 Present Fellow, Glenda Garvey Teaching Academy
  • 2002 AAAAI Educational Research Trust Faculty Development Award
  • 1995-1996 Medical Chief Resident
  • Louis P. Markey Fellowship

About Stephen Canfield

Dr. Stephen Canfield is a board certified Allergist/Immunologist and member of the American Academy of Allergy, Asthma, and Immunology. He is an Assistant Professor of Medicine at CUMC in the division of Pulmonary, Allergy, and Critical Care Medicine.

Dr. Canfield earned his PhD in Immunology and Microbiology at Columbia University and went on to earn his MD there as well. He completed residency training in Internal Medicine at New York Presbyterian Hospital, where he served as Chief Medical Resident. He subsequently completed clinical training in Allergy and Immunology at Columbia University and has been practicing since 2001. In addition to clinical practice, Dr. Canfield serves as the Associate Program Director for the Allergy/Immunology clinical training program, and directs the Immunology Section of the major preclinical medical student course. He also serves as a curriculum advisor to medical schools in Southern Africa and in the Dominican Republic.

Academic Titles

  • Assistant Professor of Medicine at CUMC

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Languages

  • Spanish

Gender

  • Male

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Affinity

  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Amida Care

  • Special Needs Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • HMO
  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

POMCO

  • POMCO

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • Medicare Managed Care
  • SelectHealth

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Contact & Locations

1
161 Fort Washington Avenue
Room 310
New York, New York 10032
Phone:
(212) 305-1544
Fax:
(212) 342-3895
Primary
2
51 West 51st Street
Suite 360B
New York, New York 10019
Phone:
(212) 305-1544

Research

Dr. Canfield completed his doctoral training in the area of immunoglobulin structure and effector function with Dr. Sherie Morrison at UCLA. Following an internal medicine residency, he transitioned into T cell biology, studying the mechanisms by which activated T cells adhere to extracellular matrix (ECM) in a post-doctoral fellowship with Dr. Seth Lederman at the Columbia University College of Physicians and Surgeons. These studies led to the discovery that a receptor for laminin previously associated only with tumor metastasis mediates laminin adherence in activated CD4+ T lymphocytes.

Dr. Canfield went on to pursue clinical training in the field of Allergy/Immunology at Columbia with Dr. Paul Rothman, during which time he developed a murine model recapitulating the genetic predisposition to asthma associated with single nucleotide polymorphisms in the human IL-4 receptor alpha chain. These studies led to the discovery of a novel IL-4 signaling pathway mediated by members of the MAP kinase signaling family.

The murine model of IL-4 receptor SNP effects remains one of the ongoing research endeavors in Dr. Canfield's lab. In the past two years, the lab's interests have moved in a translational direction with two projects directly examining the response of human peripheral blood T cells to a variety of antigen stimuli in vitro. One project, examining the effects of environmental tobacco smoke (ETS) on the development of allergies and asthma, focuses on a sample of children recruited from NYC neighborhoods with high rates of asthma and allergy. Current studies aim to characterize the T cell proliferative and cytokine response to these allergens among sensitized and non-sensitized individuals, and to identify effects of ETS exposure on the T cell allergen-specific response. In a second translational study, Dr. Canfield has joined a collaborative effort with Drs. Chess and Jiang examining mechanisms of peripheral immune regulation. Previous work by Drs. Jiang and Chess in a murine model of autoimmunity identified a population of CD8+ T lymphocytes capable of suppressing autoreactive CD4+ effector T cells and preventing emergence of autoimmune disease. Evidence from this model regarding the mechanism by which CD4+ T cells are targeted for suppression suggests that this regulatory process may be important in the avoidance of a variety of "inappropriate" immune responses, including autoimmune and allergic responses in humans. The aim of these collaborative studies is to apply the evidence gathered in the mouse system to characterize the orthologous regulatory system in humans. Among the disease conditions under study are type 1 diabetes mellitus, allergic rhinitis, and asthma.

In summary, Dr. Canfield's research interests involve both basic and translational approaches toward an overarching aim of elucidating the mechanisms underlying the maladaptive T cell immune responses that precipitate allergy and autoimmunity.

Research Interests

  • Characterization of the molecular signaling events that follow interleukin-4 (IL-4) stimulation of B and T Cells.
  • Particular interest in the molecular mechanizm by which singular nucleotide polymorphisms in the gene encoding the IL-4 receptor alpha chain are associated with increased susceptibility to asthma and atopic disease in humans.

Grants

CAREER TRACKS TOWARDS EXCELLENCE (Private)

Jul 1 1993 - Jun 30 2012

Selected Publications

Canfield, S., Lee, Y., Shröder, A., Rothman, P. Cutting Edge: IL-4 Induces Suppressor of Cytokine Signaling-3 Expression in B Cells by a Mechanism Dependent on Activation of p38 MAPK. 2005. J. Immunol. 174(5):2494-2498.
 
Chew, GL., Perzanowski, MS., Canfield, SM, et al. Cockroach Allergen Levels and Associations with Cockroach-specific IgE. 2008. J. Allergy Clin Immunol 121:240-245.
 
Perzanowski, MS, Canfield, SM, Chew, GL, et al. Birth Order, Atopy, and Symptoms of Allergy and Asthma Among Inner-city Children Attending Head Start in New York City. 2008. Clin Exp Allergy. 38(6): 968-976.
 
Jacobson, JS, Goldstein, IF, Canfield, SM, et al. Early Respiratory Infections and Asthma Among New York City Head Start Children. 2008. J. Asthma. 45:301-308.
 
Canfield, SM, Jacobson, JS, Perzanowski, MS, et al. Total and Specific IgE Associations between New York City Head Start Children and their Parents. 2008. J. Allergy Clin Immunol. 121(6):1422-1427.
 
Jelic, S, Padeletti, M, Kawut, SM, Higgins, C, Canfield, SM, Duygu, O, Colombo, PC, Basner, RC, Factor, P, LeJemtel, TH. Inflammation, Oxidative Stress, and Repair Capacity of the Vascular Endothelium in Obstructive Sleep Apnea. 2008. Circulation. 117:2270-2278.
 
Rotsides DZ, Goldstein, IF, Canfield, SM, Perzanowski, et al. Asthma, Allergy, and IgE Levels In NYC Head Start Children. 2010. Respiratory Medicine. 104(3):345-355.
 
Mehra, D, Sternberg, DI, Jia, Y, Canfield, S, Lemiatre, V, Nkyimbeng, T, Wilder, J, Sonett, J, D’Armiento, J. Altered Lymphocyte Trafficking and Diminished Airway Reactivity in Transgenic Mice Expressing Human MMP-9 in a Mouse Model of Asthma. 2010. Am J Physiol Lung Mol Physiol. 298(2): L189-96.
 
Kashiwada, M, Levy, D, McKeag, L, Murray, K, Schroder, AJ, Canfield, SM, Traver, G, Rothman, PB. IL-4-Induced Transcription Factor NFIL3/E4BP4 Controls IgE Class Switching. 2010. PNAS 107:821-826.
 
Rastogi, D, Canfield, SM, Andrade, A, Isasi, CR, Hall, CB, Rubinstein, A, Arens, R. Obesity-Associated Asthma in Children – A Distinct Entity. 2011. Chest. [Epub ahead of print]