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Stephen M. Lagana, MD

Board Certifications: 
Anatomic Pathology
Expertise in: 
Pathology - Anatomic, Gastrointestinal Pathology
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Credentials & Experience

Board Certifications

  • Anatomic Pathology

Clinical Expertise

  • Celiac Disease
  • Hepatocellular Carcinoma
  • Inflammatory Bowel Diseases (IBD)
  • Liver Biopsy
  • Liver Pathology
  • Liver Tumors
  • Surgical Pathology


Education & Training

  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center

About Stephen Lagana

I am a surgical pathologist with sub-specialty expertise in GI and liver pathology. I am also the Quality Assurance Director for Anatomic Pathology. I graduated from University of Pittsburgh School of Medicine and performed my residency and fellowship at Columbia University.


Academic Titles

  • Associate Professor of Pathology & Cell Biology at CUMC

Committee/Societies/Council Memberships



Roger Haggitt GI Pathology Society

NY Path Society

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center


  • Male

Insurance Accepted


  • EPO
  • HMO
  • Medicare Managed Care
  • NYP Employee Plan
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health


  • Medicare Managed Care
  • Special Needs Plan

Capital District Physician Health Plan

  • Capital District Physician Health Plan


  • EPO
  • Great West
  • HMO
  • POS
  • PPO


  • Medicare Managed Care
  • PPO


  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross/Blue Shield

  • EPO
  • Medicare Managed Care
  • PPO

Local 1199

  • Local 1199


  • MagnaCare


  • Multiplan

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty


  • Columbia University Employee Plan
  • Compass (Exchange)
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

*Please contact the provider’s office directly to verify that your particular insurance is accepted.


Research Interests

  • I am interested in non-neoplastic small bowel disease (e.g. celiac disease) and liver neoplasia.

Selected Publications

Gonzalez RS, Lagana SM, Szeto O, Arnold CA. Challenges in Diagnosing Medication Resins in Surgical Pathology Specimens: A Crystal-Clear Review Guide. Arch Pathol Lab Med. 2017 Feb 7. doi: 10.5858/arpa.

Hemant Varma, Phyllis L. Faust, Alejandro D. Iglesias, Stephen M. Lagana, Karen Wou, Michio Hirano, Salvatore DiMauro, Mahesh M. Mansukani, Kirsten E. Hoff, Peter L. Nagy, William C. Copeland, Ali B. Naini. Whole exome sequencing identifies a homozygous POLG2 missense variant in an infant with fulminant hepatic failure and mitochondrial DNA depletion. Eur J Med Gen. 2016

Sung D, Iuga AC, Kato T, Martinez M, Remotti HE, Lagana SM.

Crypt Apoptotic Body Counts in Normal Ileal Biopsies Overlap with Graft Versus Host Disease and Acute Cellular Rejection of Small Bowel Allografts. Hum Pathol. 2016 May 28. pii: S0046-8177(16)30098-3. doi: 10.1016/j.humpath.2016.05.017. [Epub ahead of print] PMID: 27246175

Elizabeth Margolskee; Fei Bao; Anne Koehne de Gonzalez; Roger K Moreira; Stephen M Lagana; Anthony N Sireci; Antonia R Sepulveda; Helen E Remotti; Jay H Lefkowitch; Marcela Salomao, MD. Hepatocellular Adenoma Classification: A Comparative Evaluation of Immunohistochemistry and Targeted Mutational Analysis. Diagn Pathol. 2016 Mar 9;11(1):27. doi: 10.1186/s13000-016-0475-5.

Nina Burbure, Benjamin Lebwohl, Peter H.R. Green, Carolina Arguelles-Grande, Govind Bhagat, Stephen M. Lagana. Olmesartan Associated Sprue-like Enteropathy: a Systematic Review with Emphasis on Histopathology. Hum Pathol. 2016 Apr;50:127-34. doi: 10.1016/j.humpath.2015.12.001.

Taylor SA, Vittorio JM, Martinez M, Fester KA, Lagana SM, Lobritto SJ, Ovchinsky N. Anakinra-Induced Acute Liver Failure in an Adolescent Patient with Still's Disease. Pharmacotherapy. 2016 Jan 9. doi: 10.1002/phar.1677

Lefkowitch J, Lagana SM, Kato T. Hepatocellular Carcinoma in Noncirrhotic Liver with Glycogenotic Foci: Basic Science Meets Genomic Medicine. Semin Liver Dis. 2015 Nov;35(4):450-6. doi: 10.1055/s-0035-1568986

Stephen Lagana, Susan Hsiao, Fei Bao, Antonia Sepulveda, Roger Moreira, Jay Lefkowitch and Helen Remotti. HepPar-1 and Arginase-1 Immunohistochemistry in Adenocarcinoma of the Small Intestine and Ampullary Region. Archives of Pathology & Laboratory Medicine Jun 2015, Vol. 139, No. 6 (June 2015) pp. 791-795

Armando, Del Portillo, Stephen M, Lagana, Yuan, Yao, Takeshi, Uehara, Nirag, Jhala, Tapan, Ganguly, Peter, Nagy, Jorge, Gutierrez, Aesis, Luna, Julian, Abrams, Yang, Liu, Randall, Brand, Jorge L, Sepulveda, Gary W, Falk, Antonia R, Sepulveda. Evaluation of Mutational Testing of Pre-neoplastic Barrett's Mucosa by Next Generation Sequencing of FFPE Endoscopic Samples for Detection of Concurrent Dysplasia and Adenocarcinoma in Barrett's Esophagus. J Mol Diagn. 2015 Jul;17(4):412-9.

Anne K Koehne de Gonzalez, Marcela A Salomao and Stephen M Lagana. Current concepts in the immunohistochemical evaluation of liver tumors

World J Hepatol 7(10):1403-1411. Published online 2015 June 08. doi: 10.4254/wjh.v7.i10.1403

Lagana SM, Salomao M, Remotti HE, Knisely A.S., Moreira RK. Bile Salt Export Pump: a Sensitive and Specific Immunohistochemical Marker of Hepatocellular Carcinoma. Histopathology. 2015 Mar;66(4):598-602. doi: 10.1111/his.12601.

Melissa Latorre MD, Stephen M. Lagana MD, Daniel E. Freedberg MD, Benjamin Lebwohl MD, Govind Bhagat MD, Suzanne K. Lewis MD, Peter H.R. Green MD. Endoscopic biopsy technique in the diagnosis of celiac disease: one bite or two? Gastrointest Endosc. 2015 Jan 29. pii: S0016-5107(14)02380-3

Lagana SM, Braunstein ED, Arguelles-Grande C, Bhagat G, Green PH, Lebwohl B. Sprue-like histology in patients with abdominal pain taking olmesartan compared with other angiotensin receptor blockers. J Clin Pathol. 2015 Jan;68(1):29-32. doi: 10.1136/jclinpath-2014-202615.

Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR. An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard.Clin Imaging. 2014 Jun 4. pii: S0899-7071(14)

Hanna RF, Finkelstone LA, Chow DS, Miloushev VZ, Escudero MR, Lagana SM, Prince MR. Nephrogenic systemic fibrosis risk and liver disease. Int J Nephrol. 2014;2014:679605. doi: 10.1155/2014/679605. Epub 2014 Mar 23.PMID:24778878

Chen, X., Lagana, SM., Poneros, J., Kato, T., Remotti, F., He, H., Kaminsky, D. and Hamele-Bena, D. (2013), Cytological diagnosis of angiosarcoma arising in an immunosuppressed patient 6 years after multi-visceral transplantation. Diagn. Cytopathol.. doi: 10.1002/dc.23068

Lagana SM, Moreira, RK, Remotti HE, Bao F. Glutamine synthetase, Heat-shock Protein 70 and Glypican-3 in Intra-hepatic Cholangiocarcinoma and Tumors Metastatic to Liver. Appl Immunohistochem Mol Morphol. 2013 May;21(3):254-7. doi: 10.1097/PAI.0b013e3182642c9c.

Lagana SM, Salomao M, Bao F, Moreira RK, Lefkowitch, J, Remotti HE. Utility of an Immunohistochemical Panel Consisting of Glypican-3, Heat Shock Protein-70, and Glutamine Synthetase in the Distinction of Low-grade Hepatocellular Carcinoma from Hepatocellular Adenoma. Appl Immunohistochem Mol Morphol. 2013 Mar;21(2):170-6. doi: 10.1097/PAI.0b013e31825d527f.

Lagana SM, Taub RN, Borczuk AC. Utility of Glucose Transporter 1 in the Distinction of Benign and Malignant Thoracic and Abdominal Mesothelial Lesions. Arch Pathol Lab Med. 2012 Jul;136(7):804-9. doi: 10.5858/arpa.2011-0219-OA.

Guo-Xia Tong, Lorenzo Memeo, Cristina Colarossi, Diane Hamele-Bena, Cristina Magi-Galluzzi, Ming Zhou, Stephen M. Lagana, Lara Harik, Jennifer M. Oliver-Krasinski, Mahesh Mansukhani, Lorenzo Falcone, Hanina Hibshoosh, and Kathleen O'Toole. PAX8 and PAX2 Immunostaining Facilitates the Diagnosis of Primary Epithelial Neoplasms of the Male Genital Tract. Am J Surg Pathol. 2011 Oct;35(10):1473-83.

Lagana SM, Hanna RF, Borczuk AC. Pleomorphic (Spindle and Squamous Cell) Carcinoma Arising in a Peripheral Mixed Squamous and Glandular Papilloma in a 70 Year Old Man. Arch Pathol Lab Med. 2011 Oct;135(10):1353-6.

Lagana SM, Moreira RK, Lefkowitch JH. Hepatic Granulomas: Pathogenesis and Differential Diagnosis. Clin Liver Dis. 2010 Nov;14(4):605-17.PMID: 21055685

Lagana S, Parwani AV, Nichols L. Cardiac Sarcoidosis. A Pathology Focused Review. Arch Pathol Lab Med. 2010 Jul;134(7):1039-46.

Nichols L, Lagana S, Parwani A. Coronary Artery Aneurysm: a Review and Hypothesis Regarding Etiology. Arch Pathol Lab Med. 2008 May;132(5):823-8. Review.

London B, Michalec M, Mehdi H, Zhu X, Kerchner L, Sanyal S, Viswanathan PC, Pfahnl AE, Shang LL, Madhusudanan M, Baty CJ, Lagana S, Aleong R, Gutmann R, Ackerman MJ, McNamara DM, Weiss R, Dudley SC Jr. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias. Circulation. 2007 Nov 13;116(20):2260-8.