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Timothy Cragin Wang, MD

Board Certifications: 
Gastroenterology, Internal Medicine
Expertise in: 
Cancer Care
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Appointments

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Credentials & Experience

America's Top Doctor

Board Certifications

  • Gastroenterology
  • Internal Medicine

Clinical Expertise

  • Cancer Care
  • Peptic Ulcer Disease
  • Gastric Cancer
  • Colon Cancer Screening and Prevention

Education & Training

  • Columbia University College of Physicians and Surgeons
  • Internship: Barnes Jewish Hospital
  • Residency: Barnes Jewish Hospital
  • Fellowship: Harvard Hospitals

Honors & Awards

AGA Funderberg Gastric Cancer Award

About Timothy Wang

Academic Titles

  • Dorothy L. and Daniel H. Silberberg Professor of Medicine

Administrative Positions

  • Chief, Division of Digestive and Liver Diseases

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Gender

  • Male

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Indemnity
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Affinity

  • Access (Exchange)
  • Essential Plan
  • Medicaid Managed Care
  • Medicare Managed Care

Amida Care

  • Special Needs Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • HMO
  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Medicare

  • Traditional Medicare (NY)

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

POMCO

  • POMCO

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • SelectHealth

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Contact & Locations

1
161 Fort Washington Avenue
Suite 862
New York, New York 10032
Phone:
(212) 342-1546
Fax:
(212) 305-1081
Primary

Research

The lab has been an international leader in models of Helicobacter-mediated gastric cancer but has also developed inflammatory models of colorectal, esophageal and pancreatic neoplasia. The lab is part of the NCI-sponsored Tumor Microenvironment Network (TMEN), and has investigated roles for cancer-associated fibroblasts (CAFs) and myeloid-derived suppressor cells (MDSCs) in carcinogenesis. Finally, the laboratory is deeply engaged in studies of stem cells, including bone marrow-derived stem cells and resident tissue stem cells in the gastrointestinal tract, and the events that can lead to conversion to cancer stem cells. The major current focus of Dr. Wang's laboratory is the nature of the association between inflammation and carcinogenesis, and in particular the role of chronic inflammation in the initiation of gastrointestinal cancer.

His group was one of the first to demonstrate roles for bone marrow-derived stem cells (BMDC's) in contributing to gastric cancer (Science 2004), and his group has continued to explore roles for BMDC's as precursors of cancer-associated fibroblasts, myeloid derived suppressor cells and also dysplastic epithelial cells.

Dr. Wang leads a team of U54-funded investigators and the Tumor Microenvironment program at Columbia that are exploring broadly the role of the tumor microenvironment in promoting the growth of both gastric and liver cancer. Dr. Wang's laboratory was the first to show that overexpression of a single proinflammatory cytokine (IL-1beta) can induce cancer in a mouse (Cancer Cell 2008).

Chronic inflammation leads to an expansion of resident tissue stem cells in the gastrointestinal tract, and Dr. Wang's laboratory has identified several markers for both quiescent stem cells and progenitor cells and is actively performing Cre-mediated lineage tracing studies to elucidate the early events in carcinogenesis. In addition, Dr. Wang's laboratory has active murine models and projects related to the role of chronic inflammation in promoting colorectal cancer, esophageal cancer, and pancreatic cancer.

Dr. Wang began his research career in the area of gastrin biology, and his research has continued to explore the role of gastrin peptides in diverse diseases including peptic ulcer disease, gastric cancer, and colorectal cancer. His laboratory was the first to generate gastrin knockout mice and to demonstrate using transgenic technology in vivo roles for progastrin. Most recently, he has demonstrated a role for progastrin and the gastrin receptor in modulating colonic stem cell symmetric division (J. Clin. Invest. 2009). He has been a leader in the field of gastrin biology, and his work in the field of gut hormones has included organizing the International Conference on Gastrin (1999) and the International Regulatory Peptide Conference (2002).

Research Interests

  • Understanding the role of chronic inflammation in modulating stem cells and the tissue microenvironment in ways that predispose to gastrointestinal cancers

Grants

THE ROLE OF STEM CELLS AND THE MICROENVIRONMENT IN GASTROINTESTINAL CANCERS (Federal Gov)

Dec 7 2016 - Nov 30 2023

THE ROLE OF THE MICRO ENVIRONMENT IN BARRETT S ESOPHAGUS (Federal Gov)

May 12 2017 - Apr 30 2022

FUSOBACTERIUM NUCLEATUM-MEDIATED STIMULATION OF COLORECTAL CANCER: MECHANISTIC STUDIES (Federal Gov)

Dec 1 2014 - Nov 30 2019

MULTIDISCIPLINARY TRAINING IN TRANSLATIONAL GASTRINOINTESTINAL AND LIVER RESEARCH (Federal Gov)

Jul 1 2014 - Jun 30 2019

MOUSE MODELS OF GASTRIC CANCER (Federal Gov)

Jan 13 2014 - Nov 30 2018

DF/HCC SPORE IN GASTROINTESTINAL CANCER (Federal Gov)

Sep 23 2013 - Jun 30 2018

CHEMOPREVENTION OF ESOPHAGEAL CANCER IN A MOUSE MODEL OF BARRET S ESOPHAGUS (Federal Gov)

Sep 18 2015 - Sep 17 2017

GI TRACT DYSBIOSIS AND BREAST CANCER (Federal Gov)

Sep 26 2012 - Aug 31 2017

QUIESCENT DCLK1+ STEM CELLS IN THE MOUSE INTESTINE (Federal Gov)

Sep 1 2013 - May 31 2017

THE ROLE OF NOVEL RHO PATHWAY GENOMIC ALTERATIONS IN DIFFUSE GASTRIC CANCER (Private)

Feb 1 2015 - Jan 31 2017

ROLE OF NEURONS IN THE DEVELOPMENT AND PROGRESSION OF PANCREATIC CANCER (Private)

Jan 1 2013 - Dec 31 2016

PRECLINICAL STUDIES WITH MDX 400 IN MOUSE MODELS OF GASTRIC CANCER (Private)

Sep 10 2014 - Sep 9 2016

MYOFIBROBLASTS IN GASTROINTESTINAL CANCERS (Federal Gov)

Sep 22 2011 - Jul 31 2016

THE FUNCTION AND REGULATION OF HISTIDINE DECARBOXYLASE IN GUT INFLAMMATION (Federal Gov)

Apr 1 2011 - Mar 31 2016

MOLECULAR PATHOGENESIS AND TREATMENT OF MNGIE (Federal Gov)

Apr 1 2010 - Jan 31 2016

DCLK1 IN PANCREATIC TUMORIGENESIS (Private)

Jul 1 2013 - Jun 30 2015

THE FUNCTION AND REGULATION OF TREFOIL FACTOR FAMILY 2 (TFF2) (Federal Gov)

Apr 1 2001 - Jun 30 2014

INFLAMMATION AND THE ESOPHAGEAL TUMOR MICROENVIRONMENT (Federal Gov)

Oct 1 2009 - Aug 31 2013

THE INFLUENCE OF HEDGEHOG PATHWAY INHIBITION ON PANCREATIC CANCER METASTASIS (Private)

Jul 1 2010 - Jun 30 2013

CHEMOPREVENTION IN A NOVEL MOUSE MODEL OF BARRETT S ESOPHARGUS AND ESOPHAGEAL ADENOCARCINOMA (Federal Gov)

Nov 1 2010 - Apr 29 2013

CHEMOPREVENTION IN A NOVEL MOUSE MODEL OF BARRETT''S ESOPHARG US AND ESPHAGEAL (Federal Gov)

Nov 1 2010 - Apr 29 2013

INFLAMMATION AND THE SEPOHANGEAL TUMOR MICROENVIRONMENT (Federal Gov)

Oct 1 2009 - Aug 31 2012

THE ROLE OF INFLAMMATION AND STROMA IN DIGESTIVE CANCER (Federal Gov)

Sep 30 2006 - Aug 31 2012

STEM CELLS AND GASTRIC CANCER (Federal Gov)

Sep 1 2006 - Jul 31 2012

ROLE OF STEM CELLS IN GASTRIC CANCER (Private)

Nov 17 2008 - Mar 31 2012

THE ROLE OF INFLAMMATION AND STEM CELLS IN COLON CARCINOGENE SIS (Private)

Jul 1 2010 - Jun 30 2011

INDUCED PLURIPTOTENT STEM (IPS) CELLS DERIVED FROM MESENCHYM AL STEM CELLS (NY State Gov)

Jan 1 2009 - Dec 31 2010

Selected Publications

  • Wang TC, Cardiff RD, Zuckerberg L, Lees E, Arnold A, and Schmidt EV. (1994) Mammary hyperplasia and carcinoma in MMTV-Cyclin D1 transgenic mice. Nature 369:669-71
  • Fox JG, Beck P, Dangler CA, Whary MT, Wang TC, Shi HN, and Anderson CN. (2000) Concurrent enteric helminth infection modulates inflammation, gastric immune responses, and reduces Helicobacter-induced gastric atrophy. Nature Medicine 6:536-42
  • Houghton J, Stoicov C, Nomura S, Rogers AB, Carlson J, Li H, Cai X, Fox JG, Goldenring JR, Wang TC. (2004) Gastric cancer originating from bone marrow-derived cells. Science 306:1568-71
  • Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, Betz KS, Penz-Oesterreicher M, Bjorkdahl O, Fox JG, Wang TC. (2008) Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer Cell 14:408-19
  • Takaishi S, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC.
  • (2009) Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells 27:1006-20
  • Jin G, Ramanathan V, Baik GH, Wang SSW, Tu S, Pritchard DM, Varro A, Shulkes A, Wang TC. (2009 ) Inactivation of the cholecystokinin-2 receptor inhibits progastrin-dependent crypt fission, colonic proliferation and colorectal cancer. Journal of Clinical Investigation Sept: