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Jeanine M. D'Armiento, MD, PhD

Board Certifications: 
Internal Medicine, Pulmonary Disease Medicine
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Credentials & Experience

Board Certifications

  • Internal Medicine
  • Pulmonary Disease Medicine

Clinical Expertise

  • Lung Disease
  • Pulmonology
  • Vascular Disease

Education & Training

  • UMDNJ/Robert Wood Johnson Medical School
  • 1992 UMDNJ-Robert Wood Johnson Medical School
  • Internship: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Residency: 1995 NewYork-Presbyterian/Columbia University Medical C
  • Fellowship: NewYork-Presbyterian Hospital/Columbia University Medical Center
  • Fellowship: 1998 NewYork-Presbyterian/Columbia University Medical C

Honors & Awards

  • 1985 Henry Rutgers Scholar Honors
  • 1993 Research Award for Trainees, National Institutes of Health
  • 1996 Burroughs Welcome Career Award
  • 1997 Dewitt S. Goodman Fellowship
  • 2000 UMDNJ Distinguished Alumni Award
  • 2003 American Society of Clinical Investigation
  • 2007-2012 Established Investigator Award-American Heart Association

About Jeanine D'Armiento

We are dedicated to the comprehensive evaluation of patients with lymphangioleiomyomatosis and other lung diseases in parallel with a commitment to basic research and application of principles to the therapeutic aspects of lung disease.

Jeanine D’Armiento, M.D, Ph.D. has been caring for patients with LAM for over ten years. She received her M.D. and Ph.D. from UMDNJ-Robert Wood Johnson, and completed Internal Medicine residency and Pulmonary fellowship at Columbia University Medical Center.

Her research focus in LAM centers on the role of HMGA2 in disease pathogenesis. She has been performing pulmonary research for more than 15 years, with interests in LAM, emphysema, and lung injury and repair.

Academic Titles

  • Assistant Professor of Medicine (in Anesthesiology)

Administrative Positions

  • Associate Dean for Gender Equity and Career Development

Hospital Affiliations

  • NewYork-Presbyterian / Columbia University Irving Medical Center

Gender

  • Female

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NYP Employee Plan
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Affinity

  • Essential Plan
  • Medicaid Managed Care

AgeWell

  • Medicare Managed Care
  • Special Needs Plan

Amida Care

  • Special Needs Plan

Capital District Physician Health Plan

  • Capital District Physician Health Plan

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Elderplan

  • Medicare Managed Care

Emblem/GHI

  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • EPO
  • Medicare Managed Care
  • PPO

Empire Blue Cross Blue Shield HealthPlus

  • Child/Family Health Plus
  • Essential Plan
  • Medicaid Managed Care

Fidelis Care

  • Child/Family Health Plus
  • Medicaid Managed Care
  • Medicare Managed Care

Healthfirst

  • Child/Family Health Plus
  • Leaf (Exchange)
  • Medicaid Managed Care
  • Medicare Managed Care

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Medicare

  • Traditional Medicare (NY)

MVP Health Care

  • Child/Family Health Plus
  • Essential Plan
  • HMO
  • Medicaid Managed Care

Oxford Health Plans

  • Freedom
  • Liberty

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

VNSNY CHOICE

  • Medicare Managed Care
  • SelectHealth
  • Special Needs Plan

WellCare

  • Medicaid Managed Care
  • Medicare Managed Care

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Research

We are a multi-disciplinary center focusing on the care of patients with LAM and other rare lung diseases. In addition to the care of patients with LAM, we conduct both clinical and basic science research focusing on this disease.

The research in our laboratory centers on several projects directed at understanding the role of matrix metalloproteinases in tissue destruction during disease processes. Our laboratory has made use of transgenic mice in which to express these enzymes at pathophysiological levels in specific tissues so as to recreate the natural proteolytic imbalance. Through the generation of these transgenic animals we have been able to develop several mouse models of emphysema, atherosclerosis and heart failure and also gain insight into the role these enzymes may be playing in the pathogenesis of these diseases.

Several years ago we demonstrated that transgenic mice which express human MMP-1 (matrix metalloproteinase 1, interstitial collagenase) in the lung develop emphysema. We have recently demonstrated that human patients with emphysema express MMP-1 within their lung parenchyma and normal patients do not. In this study it was found that the type II pneumocyte of the lung of patients with emphysema expressed MMP-1. Therefore, we are proceeding with in vitro studies to determine the mechanism by which MMP-1 is induced in the type II pneumocyte. In our preliminary work we have found that cigarette smoke extract can induce MMP-1 expression in lung epithelial cells and this occurs through activation of the MAP Kinase signaling pathway. Through in vitro promoter studies we have identified the region of the MMP-1 promoter that responds to cigarette smoke.

These studies demonstrate that cigarette smoke induced changes on the epithelial cell of the lung from patients with emphysema may be critical in disease pathogenesis. Our future studies will attempt to identify the molecular pathway leading to up regulation of MMP-1 and other genes in the emphysema lung and possibly provide us with alternative drug targets for this disease. 

 

Research Interests

  • Lung physiology and pathology, understanding the mechanisms altering lung injury and repair

Grants

Smoke Induced Airway Injury in COPD
Grant Agency: NIH – R01 HL086936
PI: Jeanine D’Armiento, M.D., Ph.D.

Inducible Macrophage Specific Gene Expression in Diseases
Grant Agency: NIH – ARRA-Challenge Grant RC HL100384
PI: Jeanine D’Armiento, M.D., Ph.D.

Novel Mechanisms of MMP Induction in Vascular Smooth Muscle Cells
Grant Agency: American Heart Association – Established Investigator Award
PI: Jeanine D’Armiento, M.D., Ph.D.

Allosteric Modulation of Cardiovascular Ion Channels
Grant Agency: NIH – P01 HL086936
PI: Arthur Karlin, Ph.D., PI
Role: Director of Core

Molecular Basis of Sudden Cardiac Death
Grant Agency: NIH – P01 HL67849
PI: Andrew Marks, M.D.
Role: Director of Core 

The Role of MMP-13 in Emphysema Development
Grant Agency: Flight Attendant Medical Research Institute
PI: Monica Goldklang, M.D.
Role: Sponsor 

Stony Wold: Training Fellowship
Grant Agency: Stony Wold-Herbert Fund, Inc.
PI: Monica Goldklang, M.D.
Role: Sponsor