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Steven L. Spitalnik, MD

Board Certifications: 
Pathology-Anatomic/Pathology-Clinical
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Credentials & Experience

Board Certifications

  • Pathology-Anatomic/Pathology-Clinical

Clinical Expertise

  • Apheresis
  • Sickle Cell Anemia
  • Transfusion Medicine
  • Blood Bank

Specialties

Education & Training

  • University of Chicago Pitzker School of Medicine
  • Internship: University of Rochester
  • Residency: University of Rochester
  • Fellowship: University of Rochester
  • Fellowship: National Institutes of Health

Honors & Awards

1974  Phi Beta Kappa

1974  Honors in Mathematics, Princeton University

1981, 1982, 1983  Young Investigator Award, Academy of Clinical Laboratory Physicians and Scientists

1987-1990  Junior Faculty Research Award, American Cancer Society

1987-1992  FIRST Award, National Institutes of Health

1989-1992  Mallinckrodt Scholar

1989  Class of `92 Commendation for Outstanding Teaching, University of Pennsylvania

1990  Class of `93 Commendation for Outstanding Teaching, University of Pennsylvania

1991  Dean's Award for Excellence in Basic Science Teaching, University of Pennsylvania

1991  US-Poland Individual Health Scientist Exchange Program Fellowship, Fogarty International Center

1992  Class of `95 Commendation for Outstanding Teaching, University of Pennsylvania

1994  Elected to American Society for Clinical Investigation

1995  Peter C. Nowell Teaching Award, University of Pennsylvania

1995  FASEB Visiting Scientist; Barry University, Miami Shores, FL. The role of glycosylation of ß-amyloid precursor protein in the pathogenesis of Alzheimer's disease.

1996  Penn Pearls Teaching Award, University of Pennsylvania

1996  Leonard Berwick Memorial Teaching Award, University of Pennsylvania

1996  Class of `99 Commendation for Outstanding Teaching, University of Pennsylvania

1997  Class of `00 Commendation for Outstanding Teaching, University of Pennsylvania

1997  Annual Meeting of the American Association of Blood Banks, Denver, CO. Workshop organizer and speaker: A Transfusion Medicine Primer

1998  Christian R. and Mary F. Lindback Foundation Teaching Award, University of Pennsylvania

1999  Sherwood Smith Memorial Lectureship, New York Association of Blood Banks Annual Meeting, Rochester, NY. The impact of molecular biology on the practice of transfusion medicine.

2002  Faculty Mentor Award, 4th Annual Marvin J. Hoffman Day, University of Rochester

2002  Short course on the biochemistry of the red blood cell membrane, Annual Meeting of the American Association of Blood Banks, Orlando, FL. Glycobiology of the red blood cell membrane

2002  Short course on human carbohydrate blood group antigens, Annual Meeting of the American Association of Blood Banks, Orlando, FL. The Lewis blood group system

2003  Eric A. Schenk Award for Excellence in Teaching, University of Rochester

2005  Gerald T. Evans Award for outstanding leadership and service to the academy, Academy of Clinical Laboratory Physicians & Scientists

2013  Graham A. Jamieson Memorial Lectureship, American Red Cross

2013  Emily Cooley Award and Lectureship, American Association of Blood Banks

2016  Elected to Hall of Fame, National Blood Foundation

2016  Inaugural Class, Academy of Clinical Mentoring and Excellence, Columbia University College of Physicians & Surgeons

About Steven Spitalnik

Dr. Steven Spitalnik, MD is the Co-Director of the Laboratory of Transfusion Biology, which pursues NIH-funded research aimed at improving transfusion practice. Dr. Spitalnik is a Professor of Pathology and Cell Biology and the Vice-Chairman of Laboratory Medicine at Columbia University Medical Center (CUMC). As the Medical Director of the Clinical laboratories on the CUMC campus of the New York-Presbyterian Hospital, he coordinates the clinical service, educational, and scholarly activities of the Division. He has been a Member of Scientific and Medical Advisory Board at Theranos, Inc. since April 7, 2016. He is a long-standing member of the Academy of Clinical Laboratory Physicians & Scientists, serving as its President in 2002-03 and, in 2005, receiving its Gerald T. Evans Award for outstanding leadership and service to the Academy. In addition to being board certified in both Anatomic and Clinical Pathology, Dr. Spitalnik is a member of the Editorial Boards of Transfusion, Transfusion Medicine Reviews, and Current Opinion in Hematology, and is the lead author of Clinical Pathology Board Review.

Email: ss2479@cumc.columbia.edu

Academic Titles

  • Professor of Pathology & Cell Biology

Administrative Positions

  • Vice-Chair for Laboratory Medicine
  • Director of Clinical Laboratories, Columbia University Medical Center Campus of New York Presbyterian Hospital

Committee/Societies/Council Memberships

1984-present  Society for Glycobiology

1984-present  American Federation for Clinical Research

1984-present  American Association of Blood Banks

1992-1993  Member, Academic Transfusion Medicine Committee

1993-1997  Member, Selection of Scientific Abstracts Committee

1995-1998  Member, Transfusion Practices Committee

1998-2000  Member, Transfusion Practices Program Committee

2007-2012  Member, Selection of Scientific Abstracts

2010-2012  Member, Nominating Committee

2013-present  Karl Landsteiner Award Selection Committee, Member (2013-present), Co-Chair (2015), Chair (2016)

1985-present  International Glycoconjugate Society

1985-present  International Society of Blood Transfusion

1986-present  American Society of Investigational Pathology (FASEB)

2009-2013  Member, Education Committee

1987-present  Academy of Clinical Laboratory Physicians and Scientists

1987-1988  Member, Committee on Long Range Planning

1991-1994  Member, Nominating and Awards Committee

1997-2003  Member, Executive Council

1998-1999   Member, Program and Finance Committee

1998-2002  Executive Director, Young Investigator Award Program

1999-2003  President-Elect, President, Immediate Past President, and Past President

2001-2002  Chair, Nominating and Awards Committee

2002-2003  Chair, Publications Committee

2003-2013  Representative to the Council of Academic Societies

2013-2014  Representative to the Council of Faculty and Academic Societies

2010-2014  Member, Publications Committee

2015  Member, Grant Review Committee

1994-present  American Society for Clinical Investigation

1998-2002  Universities Associated for Research and Education in Pathology

1998-2002  Member, Executive Committee

2001-2002  Vice-President

2003-present  Society for Leukocyte Biology

2003-2013  Council of Academic Societies

2003-2013  Representative from the Academy of Clinical Laboratory Physicians and Scientists

2005, 2007, 2009  Member, Nominating Committee

2007, 2008  AAMC appointee to the Selection Committee for the Alpha Omega Alpha Robert J. Glaser Distinguished Teacher Awards

2009-2010  Member, Program Committee

2013-2014  Council of Faculty and Academic Societies

2013-2014  Representative from the Academy of Clinical Laboratory Physicians and Scientists

2014  Member, Basic Science Task Force

2008-present  American Society of Hematology

2008, 2009, 2011, 2014  Selection of Scientific Abstracts Committee

2010-2013  Member, Scientific Committee on Transfusion Medicine

2012  Vice-Chair, Scientific Committee on Transfusion Medicine

2013  Chair, Scientific Committee on Transfusion Medicine

2014-present   International Society of Blood Transfusion

Hospital Affiliations

  • NewYork-Presbyterian/Columbia

Gender

  • Male

Insurance Accepted

Aetna

  • EPO
  • HMO
  • Medicare Managed Care
  • NY Signature
  • POS
  • PPO
  • Signature Administrators
  • Student Health

Cigna

  • EPO
  • Great West
  • HMO
  • POS
  • PPO

Emblem/GHI

  • HMO
  • Medicare Managed Care
  • PPO

Emblem/HIP

  • ConnectiCare
  • EPO
  • Essential Plan
  • HMO
  • Medicaid Managed Care
  • Medicare Managed Care
  • POS
  • PPO
  • Select Care (Exchange)
  • Vytra

Empire Blue Cross Blue Shield

  • Blue Priority
  • EPO
  • HMO
  • Medicare (Mediblue)
  • NYP Employee Plan
  • Pathway (Exchange)
  • POS
  • PPO

Local 1199

  • Local 1199

MagnaCare

  • MagnaCare

Multiplan

  • Multiplan

Oxford Health Plans

  • Freedom
  • Liberty
  • Medicare Managed Care

POMCO

  • POMCO

UnitedHealthcare

  • Columbia University Employee Plan
  • Compass (Exchange)
  • EPO
  • Essential Plan
  • HMO
  • Medicaid (Community Plan)
  • Medicare Managed Care
  • POS
  • PPO

*Please contact the provider’s office directly to verify that your particular insurance is accepted.

Research

My research program in the Laboratory of Transfusion Biology uses in vitro systems, mouse models, and human studies to investigate important problems related to red blood cell biology. We are particularly interested in improving the quality of red blood cell transfusions, and preventing or ameliorating the adverse effects resulting from this therapeutic intervention. As a result, we study the consequences of refrigerated storage, alloimmunization, and hemolytic transfusion reactions. We have a particular interest in the role of oxidative stress during refrigerated storage of red blood cells and its effects on red blood cell storage quality. In addition, we study the role of iron deficiency, iron supplementation, and iron metabolism in the biology of malaria, bacterial infections, and co-infections of malaria with bacterial pathogens. Results from these studies provided the impetus for the “iron hypothesis” to explain some of the adverse effects of red blood cell transfusion, particularly with regard to infectious disease.

Research Interests

  • The biology of red blood cells

Grants

COLUMBIA/CORNELL/HARLEM HOSPITAL PRECISION MEDICINE INITIATIVE HPO (Federal Gov)

Jul 6 2016 - Dec 31 2021

NEUROCOGNITIVE EFFECTS OF IRON DEFICIENCY IN BLOOD DONORS. (Federal Gov)

Dec 15 2017 - Nov 30 2021

RED BLOOD CELLS FROM IRON-DEFICIENT DONORS: RECOVERY AND STORAGE QUALITY (Federal Gov)

Aug 15 2016 - Apr 30 2021

MECHANISMS UNDERLYING IMPAIRED BACTERIAL CLEARANCE FOLLOWING TRANSFUSION OF STORAGE-DAMAGED RED BLOOD CELLS (Federal Gov)

Jul 3 2017 - Jul 2 2020

HARMFUL EFFECTS OF RED BLOOD CELL TRANSFUSIONS ARE MEDIATED BY IRON (Federal Gov)

Jun 15 2013 - Apr 30 2018

NEW YORK COLUMBIA COLLABORATIVE SPOTRIAS (Federal Gov)

Aug 1 2010 - Jul 31 2016

HARMFUL EFFECTS OF TRANSFUSION OF OLDER STORED RED CELLS: IRON AND INFLAMMATION (Federal Gov)

Sep 16 2009 - Jul 31 2014

VASCULAR EFFECTS OF INFECTION IN PEDIATRIC STROKE (Federal Gov)

Aug 5 2009 - Jul 31 2014

MOLECULAR CHARACTERIZATION OF G6PD DEFICIENCY IN THE DOMINICAN REPUBLIC (Private)

Jun 1 2013 - May 31 2014

TRAINING PROGRAM IN MOLECULAR BASIS OF HEALTH AND DISEASE (Private)

Apr 1 2010 - Mar 31 2014

MECHANISMS OF EFFECT OF IRON STATUS & INTERVENTIONS ON MALAR IA & OTHER INFECTIONS (Federal Gov)

Sep 30 2009 - Aug 31 2013

VASCULAR EFFECTS OF INFECTION IN PEDIATRIC STROKE (Federal Gov)

Aug 5 2009 - Jul 31 2013

TACROLIMUS ASSAY PROFICIENCY STUDY (Private)

Apr 12 2010 - Apr 11 2011

Selected Publications

Zimring JC, Smith N, Stowell SR, Johnsen JM, Bell LN, Francis RO, Hod EA, Hendrickson JE, Roback JD, Spitalnik SL. Strain-specific red blood cell storage, metabolism, and eicosanoid generation in a mouse model. Transfusion 54:137-148, 2014.

LaRocca TJ, Stivison EA, Hod EA, Spitalnik SL, Cowan PJ, Randis TM, Ratner AJ. Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. mBio 5(5):e01251-14, 2014.

Prestia K, Bandyopadhyay S, Slate A, Francis RO, Francis KP, Spitalnik SL, Fidock DA, Brittenham GM, Hod EA. Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice. Transfusion 54:2842-2851, 2014.

Wojczyk BS, Kim N, Bandyopadhyay S, Francis RO, Zimring JC, Hod EA, Spitalnik SL. Macrophages clear refrigerator storage-damaged RBCs and subsequently secrete cytokines in vivo, but not in vitro, in a murine model. Transfusion 54:3186-3197, 2014.

LaRocca T, Stivison E, Mal-Sarkar T, Hooven T, Hod E, Spitalnik SL, Ratner A. CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis. Cell Death and Disease 6:e1773; doi:10.1038/cddis.2015.135, 2015

Xu JZ, Francis RO, Lerebours Nadal LE, Shirazi M, Jobanputra V, Hod EA, Jhang JS, Stotler BA, Spitalnik SL, Nicholas SW. G6PD Deficiency in an HIV Clinic Setting in the Dominican Republic. American Journal of Tropical Medicine and Hygiene 93:722-729, 2015.

Waterman HR, Kapp LM, Howie HL, Hod EA, Spitalnik SL, Zimring JC. Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. Vox Sanguinis 109:148-154, 2015.

L’Acqua C, Bandyopadhyay S, Francis RO, McMahon DJ, Nellis M, Sheth S, Kernie SG, Brittenham GM, Spitalnik SL, Hod EA. Red blood cell transfusion is associated with increased hemolysis and an acute phase response in a subset of critically ill children. American Journal of Hematology 90:915-920, 2015.

Zimring JC, Spitalnik SL. Pathobiology of haemolytic transfusion reactions. Annual Review of Pathology 10:83-110, 2015.

Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NLC, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S for the State of the Science in Transfusion Medicine Working Groups. 2015 Proceedings of the National Heart, Lung, and Blood Institute’s State of the Science in Transfusion Medicine Symposium. Transfusion55:2282-2290, 2015.

Calabro S, Gallman A, Gowthaman U, Liu D, Chen P, Liu J, Krishnaswamy JK, Nascimento MSL, Xu L, Patel SR, Williams A, Tormey CA, Hod EA, Spitalnik SL, Zimring JC, Hendrickson JE, Stowell SR, Eisenbarth SC. Bridging channel dendritic cells induce immunity to transfused red blood cells, Journal of Experimental Medicine 213:887-896, 2016.