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Chronic Myelogenous Leukemia (Pediatric)

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What is chronic myelogenous leukemia?

Chronic myelogenous leukemia is a rare condition in children and adolescents. It begins in the bone marrow and occurs when the body produces too many white blood cells, which eventually build up and impede healthy blood cells from doing their work. 

What are the symptoms of chronic myelogenous leukemia?

  • Fatigue
  • Fever
  • Enlarged liver and spleen
  • Anemia
  • Bleeding
  • Pain

How is chronic myelogenous leukemia diagnosed?

  • Complete blood count
  • Blood tests that show an elevated white blood cell count
  • Bone marrow aspirate and biopsy
  • Cytogenetics to determine the presence of a specific chromosome called the Philadelphia (Ph) chromosome

What is the treatment for chronic myelogenous leukemia?

  • Chemotherapy
  • Imatinib mesylate, a targeted therapy that prevents the development of cells with the Ph mutation
  • Allogeneic stem cell transplantation