Innate Immune Defects (Pediatric)
What are innate immune defects?
Innate immune responses rely on cells that require no additional experience or encounters to function. These cells are neutrophils, monocytes, natural killer cells, basophils, mast cells, and complement proteins. Innate responses to infection should occur quickly. When they don't, an innate immune defect is often the reason.
What are the types of innate immune defects?
Specific disorders of innate immunity are:
- Toll-like receptor deficiencies
- MyD88 deficiency
- IRAK4 deficiency
- UNC93B deficiency
- Natural killer cell deficiency
- Defects in Interferon gamma and Interleukin 12
How are innate immune disorders diagnosed?
The diagnosis is made in suspected patients by measuring cytokine production after stimulation by bacterial products. Diagnosis is confirmed by genetic testing.
What is the treatment for innate immune defects?
Treatment usually involves antibiotic therapy prophylactically as well as aggressive and prompt treatment of acute infections. Some patients require immunoglobulin treatment.