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Langerhans Cell Histiocytosis (Pediatric)

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What is Langerhans cell histiocytosis?

Langerhans cell histiocytosis is not a true cancer but rather a collection of bone marrow and immune cells that aggregrate, multiply, and appear in bones, skin, lymph nodes, liver, lung, and bone marrow. This condition may be unifocal, involving only one part of the body, or multifocal where multiple lesions are present in more than one part of the body. 

Who is affected by Langerhans cell histiocytosis?

This condition affects children between 1 and 15 years old, is more prevalent in Caucasian children, and occurs in males twice as often as females.​

What are the symptoms of Langerhans cell histiocytosis?

Symptoms of this condition are:

  • Bone lesions that may be painful
  • Skin rashes 
  • Diabetes inspidius
  • Exophthalmos or bulging eyes 

How is Langerhans cell histiocytosis diagnosed?

Diagnosis entails a biopsy of the lesion.

What is the treatment for Langerhans cell histiocytosis?

Treatment of Langerhans cell histiocytosis​ includes:

  • Surgical curettage
  • Chemotherapy
  • Radiation therapy