Post-Transplant Lymphoproliferative Disease (Pediatric)
What is post-transplant lymphoproliferative disease?
This uncommon cancerous condition occurs in children given immunosuppressive therapy after receiving a solid organ transplant, such as a heart, liver, kidney, or bowel transplant. The immunosuppressive therapy is needed to prevent the graft or transplanted organ rejection. However, it also promotes T-cell proliferation, which under the influence of the Epstein-Barr Virus, causes lymphoma-like cancers.
What are the symptoms of post-transplant lymphoproliferative disease?
Symptoms of this condition are:
- Enlarged lymph nodes
- Difficulty breathing
- Gastrointestinal symptoms
How is post-transplant lymphoproliferative disease diagnosed?
Diagnosis of this condition entails:
- Radiological imaging with ultrasound, CT scans, and MRI
- PET scans
- Epstein-Barr Virus immune serological titers
What is the treatment for post-transplant lymphoproliferative disease?
Treatment of this condition includes:
- Reducing immunosuppressive medications
- Immunotherapy with Rituximab
- Anti-viral medication