Close mobile menu×
Close mobile menu

Post-Transplant Lymphoproliferative Disease (Pediatric)

Make an appointment. Call (212) 305-9770.

What is post-transplant lymphoproliferative disease?

This uncommon cancerous condition occurs in children given immunosuppressive therapy after receiving a solid organ transplant, such as a heart, liver, kidney, or bowel transplant. The immunosuppressive therapy is needed to prevent the graft or transplanted organ rejection. However, it also promotes T-cell proliferation, which under the influence of the Epstein-Barr Virus, causes lymphoma-like cancers. 

What are the symptoms of post-transplant lymphoproliferative disease?

Symptoms of this condition are:

  • Enlarged lymph nodes
  • Difficulty breathing
  • Fever
  • Gastrointestinal symptoms 

How is post-transplant lymphoproliferative disease diagnosed?

Diagnosis of this condition entails:

  • Radiological imaging with ultrasound, CT scans, and  MRI
  • PET scans
  • Epstein-Barr Virus immune serological titers
  • Biopsy

What is the treatment for post-transplant lymphoproliferative disease?

Treatment of this condition includes:

  • Reducing immunosuppressive medications
  • Chemotherapy
  • Immunotherapy with Rituximab
  • Anti-viral medication